SSH2 explained

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.^{[1] [2] [3]}

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[4]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chan SY, Chan AK, Cheung BP, etal . Identification of genes expressed during myocardial development. . Chin. Med. J. . 116 . 9 . 1329–32 . 2004 . 14527359 .
• Ohta Y, Kousaka K, Nagata-Ohashi K, etal . Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. . Genes Cells . 8 . 10 . 811–24 . 2004 . 14531860 . 10.1046/j.1365-2443.2003.00678.x . 24247372 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Soosairajah J, Maiti S, Wiggan O, etal . Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. . EMBO J. . 24 . 3 . 473–86 . 2005 . 15660133 . 10.1038/sj.emboj.7600543 . 548651 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Kligys K, Claiborne JN, DeBiase PJ, etal . The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. . J. Biol. Chem. . 282 . 44 . 32520–8 . 2007 . 17848544 . 10.1074/jbc.M707041200 . 2754063 . free .

Notes and References

1. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T . Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin . Cell . 108 . 2 . 233–46 . Feb 2002 . 11832213 . 10.1016/S0092-8674(01)00638-9 . 5576208 . free .
2. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 6 . 347–55 . Feb 2001 . 11214970 . 10.1093/dnares/7.6.347 . free .
3. Web site: Entrez Gene: SSH2 slingshot homolog 2 (Drosophila).
4. Web site: Entrez Gene: SSH2 slingshot homolog 2 (Drosophila).