SSH1 explained

For the SSH-1 protocol, see Secure Shell#Version 1

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.^{[1] [2] [3]}

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[3]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Endo M, Ohashi K, Sasaki Y, etal . Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. . J. Neurosci. . 23 . 7 . 2527–37 . 2003 . 12684437 . 10.1523/JNEUROSCI.23-07-02527.2003. 6742113 . free .
• Kaji N, Ohashi K, Shuin M, etal . Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. . J. Biol. Chem. . 278 . 35 . 33450–5 . 2003 . 12807904 . 10.1074/jbc.M305802200 . free .
• Ohta Y, Kousaka K, Nagata-Ohashi K, etal . Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. . Genes Cells . 8 . 10 . 811–24 . 2004 . 14531860 . 10.1046/j.1365-2443.2003.00678.x . 24247372 . free .
• Nishita M, Wang Y, Tomizawa C, etal . Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. . J. Biol. Chem. . 279 . 8 . 7193–8 . 2004 . 14645219 . 10.1074/jbc.M312591200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Dai S, Sarmiere PD, Wiggan O, etal . Efficient Salmonella entry requires activity cycles of host ADF and cofilin. . Cell. Microbiol. . 6 . 5 . 459–71 . 2004 . 15056216 . 10.1111/j.1462-5822.2004.00375.x . 20238982 . free .
• Nagata-Ohashi K, Ohta Y, Goto K, etal . A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. . J. Cell Biol. . 165 . 4 . 465–71 . 2004 . 15159416 . 10.1083/jcb.200401136 . 2172350 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Zhang Z, Niu Z, Yuan W, etal . Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. . Hum. Mutat. . 24 . 5 . 438 . 2005 . 15459975 . 10.1002/humu.9283 . 22946257 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Soosairajah J, Maiti S, Wiggan O, etal . Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. . EMBO J. . 24 . 3 . 473–86 . 2005 . 15660133 . 10.1038/sj.emboj.7600543 . 548651 .
• Wang Y, Shibasaki F, Mizuno K . Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. . J. Biol. Chem. . 280 . 13 . 12683–9 . 2005 . 15671020 . 10.1074/jbc.M411494200 . free .
• Nishita M, Tomizawa C, Yamamoto M, etal . Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. . J. Cell Biol. . 171 . 2 . 349–59 . 2006 . 16230460 . 10.1083/jcb.200504029 . 2171197 .
• Yamamoto M, Nagata-Ohashi K, Ohta Y, etal . Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L. . FEBS Lett. . 580 . 7 . 1789–94 . 2006 . 16513117 . 10.1016/j.febslet.2006.02.034 . 27347823 . free .
• Cai L, Marshall TW, Uetrecht AC, etal . Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. . Cell . 128 . 5 . 915–29 . 2007 . 17350576 . 10.1016/j.cell.2007.01.031 . 2630706 .
• Kligys K, Claiborne JN, DeBiase PJ, etal . The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. . J. Biol. Chem. . 282 . 44 . 32520–8 . 2007 . 17848544 . 10.1074/jbc.M707041200 . 2754063 . free .

Notes and References

1. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 1 . 65–73 . Apr 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
2. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T . Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin . Cell . 108 . 2 . 233–46 . Feb 2002 . 11832213 . 10.1016/S0092-8674(01)00638-9 . 5576208 . free .
3. Web site: Entrez Gene: SSH1 slingshot homolog 1 (Drosophila).