SSBP1 explained

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene.^{[1] [2]}

Function

SSBP 1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995).[supplied by OMIM]

See also

• SSBP4

Further reading

• Tiranti V, Rocchi M, DiDonato S, Zeviani M . Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB) . Gene . 126 . 2 . 219–25 . April 1993 . 8482537 . 10.1016/0378-1119(93)90370-I .
• Yang C, Curth U, Urbanke C, Kang C . Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution . Nature Structural Biology . 4 . 2 . 153–7 . February 1997 . 9033597 . 10.1038/nsb0297-153 . 32634194 .
• Schultz RA, Swoap SJ, McDaniel LD, Zhang B, Koon EC, Garry DJ, Li K, Williams RS . Differential expression of mitochondrial DNA replication factors in mammalian tissues . The Journal of Biological Chemistry . 273 . 6 . 3447–51 . February 1998 . 9452467 . 10.1074/jbc.273.6.3447 . free .
• Spelbrink JN, Toivonen JM, Hakkaart GA, Kurkela JM, Cooper HM, Lehtinen SK, Lecrenier N, Back JW, Speijer D, Foury F, Jacobs HT . In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells . The Journal of Biological Chemistry . 275 . 32 . 24818–28 . August 2000 . 10827171 . 10.1074/jbc.M000559200 . free .
• Müller-Höcker J, Schäfer S, Li K . Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue . Applied Immunohistochemistry & Molecular Morphology . 9 . 3 . 276–80 . September 2001 . 11556757 . 10.1097/00022744-200109000-00013 .
• Takamatsu C, Umeda S, Ohsato T, Ohno T, Abe Y, Fukuoh A, Shinagawa H, Hamasaki N, Kang D . Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein . EMBO Reports . 3 . 5 . 451–6 . May 2002 . 11964388 . 1084112 . 10.1093/embo-reports/kvf099 .
• Chen L, Segal D, Hukriede NA, Podtelejnikov AV, Bayarsaihan D, Kennison JA, Ogryzko VV, Dawid IB, Westphal H . Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development . Proceedings of the National Academy of Sciences of the United States of America . 99 . 22 . 14320–5 . October 2002 . 12381786 . 137882 . 10.1073/pnas.212532399 . 2002PNAS...9914320C . free .
• Diez-Tascón C, Dodds KG, Crawford AM . Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7 . Animal Genetics . 33 . 6 . 468 . December 2002 . 12464025 . 10.1046/j.1365-2052.2002.00938_1.x .
• Bayarsaihan D . SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1599 . 1–2 . 152–5 . September 2002 . 12479417 . 10.1016/s1570-9639(02)00376-x .
• Pocernich CB, Poon HF, Boyd-Kimball D, Lynn BC, Nath A, Klein JB, Butterfield DA . Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat . Brain Research. Molecular Brain Research . 133 . 2 . 299–306 . February 2005 . 15710247 . 10.1016/j.molbrainres.2004.10.024 .

Notes and References

1. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M . Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis . Genomics . 25 . 2 . 559–64 . January 1995 . 7789991 . 10.1016/0888-7543(95)80058-T .
2. Web site: Entrez Gene: SSBP1 single-stranded DNA binding protein 1.