SS18L1 explained

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.^[1]

Function

Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18.^[1]

Interactions

SS18L1 has been shown to interact with CREB-binding protein.^[2] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.^[3]

Further reading

• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 3 . 169–76 . June 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
• de Bruijn DR, Kater-Baats E, Eleveld M, Merkx G, Geurts Van Kessel A . Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene . Cytogenetics and Cell Genetics . 92 . 3–4 . 310–9 . 2001 . 11435705 . 10.1159/000056920 . 22518714 .
• Storlazzi CT, Mertens F, Mandahl N, Gisselsson D, Isaksson M, Gustafson P, Domanski HA, Panagopoulos I . A novel fusion gene, SS18L1/SSX1, in synovial sarcoma . Genes, Chromosomes & Cancer . 37 . 2 . 195–200 . June 2003 . 12696068 . 10.1002/gcc.10210 . 40041616 .
• Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A . Dendrite development regulated by CREST, a calcium-regulated transcriptional activator . Science . 303 . 5655 . 197–202 . January 2004 . 14716005 . 10.1126/science.1089845 . 2004Sci...303..197A . 20879721 .
• Pradhan A, Liu Y . A multifunctional domain of the calcium-responsive transactivator (CREST) that inhibits dendritic growth in cultured neurons . The Journal of Biological Chemistry . 280 . 26 . 24738–43 . July 2005 . 15866867 . 10.1074/jbc.M504018200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• de Bruijn DR, Geurts van Kessel A . Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci . Cytogenetic and Genome Research . 112 . 3–4 . 222–6 . 2006 . 16484776 . 10.1159/000089874 .

Notes and References

1. Web site: Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1.
2. Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A . Dendrite development regulated by CREST, a calcium-regulated transcriptional activator . Science . 303 . 5655 . 197–202 . January 2004 . 14716005 . 10.1126/science.1089845 . 2004Sci...303..197A . 20879721 .
3. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C . SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes . PLOS ONE . 7 . 3 . e33834 . 2012 . 22442726 . 3307773 . 10.1371/journal.pone.0033834 . 2012PLoSO...733834M . free .