SRXN1 explained

Sulfiredoxin-1 is a protein that in humans is encoded by the SRXN1 gene.^[1]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Venter JC, Adams MD, Myers EW, etal . The sequence of the human genome . Science . 291 . 5507 . 1304–51 . 2001 . 11181995 . 10.1126/science.1058040 . 2001Sci...291.1304V . free .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chang TS, Jeong W, Woo HA, etal . Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine . J. Biol. Chem. . 279 . 49 . 50994–1001 . 2005 . 15448164 . 10.1074/jbc.M409482200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Woo HA, Jeong W, Chang TS, etal . Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins . J. Biol. Chem. . 280 . 5 . 3125–8 . 2005 . 15590625 . 10.1074/jbc.C400496200 . free .
• Jönsson TJ, Murray MS, Johnson LC, etal . Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin . Biochemistry . 44 . 24 . 8634–42 . 2005 . 15952770 . 10.1021/bi050131i . 3928543 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Jeong W, Park SJ, Chang TS, etal . Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin . J. Biol. Chem. . 281 . 20 . 14400–7 . 2006 . 16565085 . 10.1074/jbc.M511082200 . free .
• Findlay VJ, Townsend DM, Morris TE, etal . A novel role for human sulfiredoxin in the reversal of glutathionylation . Cancer Res. . 66 . 13 . 6800–6 . 2006 . 16818657 . 6361143 . 10.1158/0008-5472.CAN-06-0484 .

Notes and References

1. Web site: Entrez Gene: SRXN1 sulfiredoxin 1 homolog (S. Cerevisiae).