SRSF2 explained

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene.^{[1] [2] [3]} MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.^[4]

Interactions

SFRS2 has been shown to interact with CDC5L^[5] and ASF/SF2.^[6]

Further reading

• Sureau A, Soret J, Vellard M, Crochet J, Perbal B . The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene . Proceedings of the National Academy of Sciences of the United States of America . 89 . 24 . 11683–11687 . December 1992 . 1465383 . 50620 . 10.1073/pnas.89.24.11683 . free . 1992PNAS...8911683S .
• Vellard M, Sureau A, Soret J, Martinerie C, Perbal B . A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon . Proceedings of the National Academy of Sciences of the United States of America . 89 . 7 . 2511–2515 . April 1992 . 1557353 . 48691 . 10.1073/pnas.89.7.2511 . free . 1992PNAS...89.2511V .
• Zahler AM, Lane WS, Stolk JA, Roth MB . SR proteins: a conserved family of pre-mRNA splicing factors . Genes & Development . 6 . 5 . 837–847 . May 1992 . 1577277 . 10.1101/gad.6.5.837 . free .
• DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP . Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system . Molecular and Cellular Biology . 7 . 1 . 379–387 . January 1987 . 3031469 . 365079 . 10.1128/mcb.7.1.379 .
• Tacke R, Manley JL . The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities . The EMBO Journal . 14 . 14 . 3540–3551 . July 1995 . 7543047 . 394422 . 10.1002/j.1460-2075.1995.tb07360.x .
• Luznik L, Martone ME, Kraus G, Zhang Y, Xu Y, Ellisman MH, Wong-Staal F . Localization of human immunodeficiency virus Rev in transfected and virus-infected cells . AIDS Research and Human Retroviruses . 11 . 7 . 795–804 . July 1995 . 7546906 . 10.1089/aid.1995.11.795 . 24916512 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL . Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors . Nature . 368 . 6467 . 119–124 . March 1994 . 8139654 . 10.1038/368119a0 . 4283089 . 1994Natur.368..119K .
• Wu JY, Maniatis T . Specific interactions between proteins implicated in splice site selection and regulated alternative splicing . Cell . 75 . 6 . 1061–1070 . December 1993 . 8261509 . 10.1016/0092-8674(93)90316-I . 22951690 .
• Sureau A, Perbal B . Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor . Proceedings of the National Academy of Sciences of the United States of America . 91 . 3 . 932–936 . February 1994 . 8302870 . 521427 . 10.1073/pnas.91.3.932 . free . 1994PNAS...91..932S .
• Fu XD . Specific commitment of different pre-mRNAs to splicing by single SR proteins . Nature . 365 . 6441 . 82–85 . September 1993 . 8361546 . 10.1038/365082a0 . 4332012 . 1993Natur.365...82F .
• Zhang WJ, Wu JY . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Molecular and Cellular Biology . 16 . 10 . 5400–5408 . October 1996 . 8816452 . 231539 . 10.1128/MCB.16.10.5400 .
• Tronchère H, Wang J, Fu XD . A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA . Nature . 388 . 6640 . 397–400 . July 1997 . 9237760 . 10.1038/41137 . 4386808 . free . 1997Natur.388..397T .
• Sureau A, Soret J, Guyon C, Gaillard C, Dumon S, Keller M, Crisanti P, Perbal B . 6 . Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene . Nucleic Acids Research . 25 . 22 . 4513–4522 . November 1997 . 9358160 . 147067 . 10.1093/nar/25.22.4513 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Zhang WJ, Wu JY . Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing . Molecular and Cellular Biology . 18 . 2 . 676–684 . February 1998 . 9447963 . 108778 . 10.1128/mcb.18.2.676 .
• Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T . Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation . Brain Research. Molecular Brain Research . 53 . 1–2 . 33–40 . January 1998 . 9473574 . 10.1016/S0169-328X(97)00262-3 .
• Parfenov VN, Davis DS, Pochukalina GN, Kostyuchek D, Murti KG . Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles . Journal of Cellular Biochemistry . 69 . 1 . 72–80 . April 1998 . 9513048 . 10.1002/(SICI)1097-4644(19980401)69:1<72::AID-JCB8>3.0.CO;2-S . 29105448 .

Notes and References

1. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG . 6 . Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2) . Genomics . 29 . 1 . 70–79 . September 1995 . 8530103 . 10.1006/geno.1995.1216 . free .
2. Fu XD, Maniatis T . Isolation of a complementary DNA that encodes the mammalian splicing factor SC35 . Science . 256 . 5056 . 535–538 . April 1992 . 1373910 . 10.1126/science.1373910 . 1992Sci...256..535F .
3. Web site: Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2.
4. Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, Haferlach T, Maciejewski JP, Corey SJ . 6 . Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms . Leukemia . 36 . 10 . 2499–2508 . October 2022 . 35941213 . 10.1038/s41375-022-01672-4 . 251408524 .
5. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–6581 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
6. Zhang WJ, Wu JY . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Molecular and Cellular Biology . 16 . 10 . 5400–5408 . October 1996 . 8816452 . 231539 . 10.1128/MCB.16.10.5400 .