SRSF2 explained

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene.[1] [2] [3] MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.[4]

Interactions

SFRS2 has been shown to interact with CDC5L[5] and ASF/SF2.[6]

Further reading

Notes and References

  1. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG . 6 . Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2) . Genomics . 29 . 1 . 70–79 . September 1995 . 8530103 . 10.1006/geno.1995.1216 . free .
  2. Fu XD, Maniatis T . Isolation of a complementary DNA that encodes the mammalian splicing factor SC35 . Science . 256 . 5056 . 535–538 . April 1992 . 1373910 . 10.1126/science.1373910 . 1992Sci...256..535F .
  3. Web site: Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2.
  4. Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, Haferlach T, Maciejewski JP, Corey SJ . 6 . Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms . Leukemia . 36 . 10 . 2499–2508 . October 2022 . 35941213 . 10.1038/s41375-022-01672-4 . 251408524 .
  5. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–6581 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
  6. Zhang WJ, Wu JY . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Molecular and Cellular Biology . 16 . 10 . 5400–5408 . October 1996 . 8816452 . 231539 . 10.1128/MCB.16.10.5400 .