SRPX explained

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene.^{[1] [2] [3]} Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin.^[4]

Further reading

• Nangaku M, Shankland SJ, Kurokawa K, etal . Cloning of a new human gene with short consensus repeats using the EST database . Immunogenetics . 46 . 2 . 99–103 . 1997 . 9162095 . 10.1007/s002510050247 . 23621385 .
• Shimakage M, Takami K, Kodama K, etal . Expression of drs mRNA in human lung adenocarcinomas . Hum. Pathol. . 33 . 6 . 615–9 . 2002 . 12152160 . 10.1053/hupa.2002.125373 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shin BK, Wang H, Yim AM, etal . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function . J. Biol. Chem. . 278 . 9 . 7607–16 . 2003 . 12493773 . 10.1074/jbc.M210455200 . free .
• Mukaisho K, Suo M, Shimakage M, etal . Down-regulation of drs mRNA in colorectal neoplasms . Jpn. J. Cancer Res. . 93 . 8 . 888–93 . 2003 . 12716466 . 5927109 . 10.1111/j.1349-7006.2002.tb01334.x.
• Kim CJ, Shimakage M, Kushima R, etal . Down-regulation of drs mRNA in human prostate carcinomas . Hum. Pathol. . 34 . 7 . 654–7 . 2003 . 12874760 . 10.1016/S0046-8177(03)00240-5 .
• Tambe Y, Isono T, Haraguchi S, etal . A novel apoptotic pathway induced by the drs tumor suppressor gene . Oncogene . 23 . 17 . 2977–87 . 2004 . 15021917 . 10.1038/sj.onc.1207419 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .

Notes and References

1. Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T . A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa . Hum Mol Genet . 4 . 12 . 2339–46 . Jul 1996 . 8634708 . 10.1093/hmg/4.12.2339 .
2. Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, etal . Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3) . Hum Mol Genet . 4 . 12 . 2347–53 . Jul 1996 . 8634709 . 10.1093/hmg/4.12.2347 .
3. Web site: Entrez Gene: SRPX sushi-repeat-containing protein, X-linked.
4. Pawłowski K, Muszewska A, Lenart A, etal . A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins . BMC Genomics . 11 . 590 . 2010 . 20964819. 10.1186/1471-2164-11-590 . 3091736 . free .