SRPK2 explained

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.^{[1] [2] [3]}

Interactions

SRPK2 has been shown to interact with:

• ASF/SF2^{[2] [4] [5]} and
• U2AF2.^[6]

Further reading

• Bedford MT, Chan DC, Leder P . FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. . EMBO J. . 16 . 9 . 2376–83 . 1997 . 9171351 . 1169838 . 10.1093/emboj/16.9.2376 .
• Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M . Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. . Biochem. Biophys. Res. Commun. . 242 . 2 . 357–64 . 1998 . 9446799 . 10.1006/bbrc.1997.7913 .
• Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M . The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs) . J. Biol. Chem. . 274 . 16 . 11125–31 . 1999 . 10196197 . 10.1074/jbc.274.16.11125 . free .
• Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J, Wissing J, Ullrich A, Cotten M . Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein . J. Virol. . 76 . 16 . 8124–37 . 2002 . 12134018 . 155132 . 10.1128/JVI.76.16.8124-8137.2002 .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Zheng Y, Fu XD, Ou JH . Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein . Virology . 342 . 1 . 150–8 . 2005 . 16122776 . 10.1016/j.virol.2005.07.030 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Gui JF, Lane WS, Fu XD . A serine kinase regulates intracellular localization of splicing factors in the cell cycle . Nature . 369 . 6482 . 678–82 . Jul 1994 . 8208298 . 10.1038/369678a0 . 1994Natur.369..678G . 4275539 . 2019-12-13 . 2020-12-03 . https://web.archive.org/web/20201203094718/http://ir.ihb.ac.cn/handle/152342/10318 . dead .
2. Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD . SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells . J Cell Biol . 140 . 4 . 737–50 . Mar 1998 . 9472028 . 2141757 . 10.1083/jcb.140.4.737 .
3. Web site: Entrez Gene: SRPK2 SFRS protein kinase 2.
4. Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K . Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A . Biochem. Biophys. Res. Commun. . 301 . 2 . 324–9 . Feb 2003 . 12565863 . 10.1016/s0006-291x(02)03017-6.
5. Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M . The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs) . J. Biol. Chem. . 274 . 16 . 11125–31 . Apr 1999 . 10196197 . 10.1074/jbc.274.16.11125. free .
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Huda Zoghbi . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .