SRI (gene) explained

Sorcin is a protein that in humans is encoded by the SRI gene.^{[1] [2]}

Interactions

SRI (gene) has been shown to interact with Ryanodine receptor 2,^[3] ANXA7^[4] and GCA.^[5]

Further reading

• Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J . Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes . Electrophoresis . 13 . 12 . 960–9 . December 1992 . 1286667 . 10.1002/elps.11501301199 . 41855774 .
• Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI . Association of sorcin with the cardiac ryanodine receptor . The Journal of Biological Chemistry . 270 . 44 . 26411–8 . November 1995 . 7592856 . 10.1074/jbc.270.44.26411 . free .
• Meyers MB, Zamparelli C, Verzili D, Dicker AP, Blanck TJ, Chiancone E . Calcium-dependent translocation of sorcin to membranes: functional relevance in contractile tissue . FEBS Letters . 357 . 3 . 230–4 . January 1995 . 7835417 . 10.1016/0014-5793(94)01338-2 . 28133606 . free .
• Wang SL, Tam MF, Ho YS, Pai SH, Kao MC . Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1260 . 3 . 285–93 . February 1995 . 7873602 . 10.1016/0167-4781(94)00206-i .
• Lee WP . Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines . Archives of Biochemistry and Biophysics . 325 . 2 . 217–26 . January 1996 . 8561500 . 10.1006/abbi.1996.0027 .
• Brownawell AM, Creutz CE . Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII) . The Journal of Biological Chemistry . 272 . 35 . 22182–90 . August 1997 . 9268363 . 10.1074/jbc.272.35.22182 . free .
• Torigoe K, Harada T, Kusaba H, Uchiumi T, Kohno K, Green ED, Scherer SW, Tsui LC, Schlessinger D, Kuwano M, Wada M . Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1 . Genomics . 49 . 1 . 14–22 . April 1998 . 9570944 . 10.1006/geno.1997.5200 .
• Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, Fishman GI . Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels . The Journal of Biological Chemistry . 273 . 30 . 18930–5 . July 1998 . 9668070 . 10.1074/jbc.273.30.18930 . free .
• Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW . Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor . The Journal of Biological Chemistry . 275 . 19 . 14440–5 . May 2000 . 10748169 . 10.1074/jbc.M909882199 . free .
• Xie X, Dwyer MD, Swenson L, Parker MH, Botfield MC . Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family . Protein Science . 10 . 12 . 2419–25 . December 2001 . 11714909 . 2374028 . 10.1110/ps.36701 .
• Li G, Tan Y, Yang C, Zhao C, Zhao H, Wang J, Xue Y, Han M, Qian L, Zhao C . Expression and clinical implication of soluble resistance-associated calcium-binding protein gene and multi-drug resistance gene in leukemia . Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology] . 24 . 4 . 370–4 . July 2002 . 12408767 .
• Li G, Tan Y, Yang C, Zhao C, Zhao H, Wang J, Xue Y, Han M, Qian L, Zhao C . Expression and clinical implications of the soluble drug resistance-related calcium-binding protein (sorcin) gene in leukemia patients . Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi . 23 . 6 . 293–6 . June 2002 . 12411058 .
• Meyers MB, Fischer A, Sun YJ, Lopes CM, Rohacs T, Nakamura TY, Zhou YY, Lee PC, Altschuld RA, McCune SA, Coetzee WA, Fishman GI . Sorcin regulates excitation-contraction coupling in the heart . The Journal of Biological Chemistry . 278 . 31 . 28865–71 . August 2003 . 12754254 . 10.1074/jbc.M302009200 . free .
• Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW . The PEF family proteins sorcin and grancalcin interact in vivo and in vitro . FEBS Letters . 545 . 2–3 . 151–4 . June 2003 . 12804766 . 10.1016/S0014-5793(03)00518-0 . 42572647 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Frank KF, Bölck B, Ding Z, Krause D, Hattebuhr N, Malik A, Brixius K, Hajjar RJ, Schrader J, Schwinger RH . Overexpression of sorcin enhances cardiac contractility in vivo and in vitro . Journal of Molecular and Cellular Cardiology . 38 . 4 . 607–15 . April 2005 . 15808837 . 10.1016/j.yjmcc.2005.01.011 .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin . The Journal of Steroid Biochemistry and Molecular Biology . 94 . 1–3 . 203–8 . February 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .

Notes and References

1. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P . Genes amplified and overexpressed in human multidrug-resistant cell lines . Cancer Research . 48 . 21 . 5927–32 . November 1988 . 2901906 .
2. Web site: Entrez Gene: SRI sorcin.
3. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI . Association of sorcin with the cardiac ryanodine receptor . The Journal of Biological Chemistry . 270 . 44 . 26411–8 . November 1995 . 7592856 . 10.1074/jbc.270.44.26411 . free .
4. Brownawell AM, Creutz CE . Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII) . The Journal of Biological Chemistry . 272 . 35 . 22182–90 . August 1997 . 9268363 . 10.1074/jbc.272.35.22182 . free .
5. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW . The PEF family proteins sorcin and grancalcin interact in vivo and in vitro . FEBS Letters . 545 . 2–3 . 151–4 . June 2003 . 12804766 . 10.1016/S0014-5793(03)00518-0 . 42572647 . free .