SRGAP3 explained

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.^{[1] [2]}

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Ishikawa K, Nagase T, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 4 . 5 . 307–13 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
• Hirosawa M, Nagase T, Ishikawa K, etal . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. . DNA Res. . 6 . 5 . 329–36 . 2000 . 10574461 . 10.1093/dnares/6.5.329 . free .
• Wong K, Ren XR, Huang YZ, etal . Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. . Cell . 107 . 2 . 209–21 . 2001 . 11672528 . 10.1016/S0092-8674(01)00530-X . 2458943 . free .
• Olave I, Wang W, Xue Y, etal . Identification of a polymorphic, neuron-specific chromatin remodeling complex. . Genes Dev. . 16 . 19 . 2509–17 . 2002 . 12368262 . 10.1101/gad.992102 . 187451 .
• Soderling SH, Binns KL, Wayman GA, etal . The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. . Nat. Cell Biol. . 4 . 12 . 970–5 . 2003 . 12447388 . 10.1038/ncb886 . 1423222 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Katoh M, Katoh M . FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. . Int. J. Mol. Med. . 11 . 6 . 791–7 . 2004 . 12736724 . 10.3892/ijmm.11.6.791.
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Yang Y, Marcello M, Endris V, etal . MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. . Exp. Cell Res. . 312 . 12 . 2379–93 . 2006 . 16730001 . 10.1016/j.yexcr.2006.04.001 .

Notes and References

1. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA . The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation . Proc Natl Acad Sci U S A . 99 . 18 . 11754–9 . Sep 2002 . 12195014 . 129341 . 10.1073/pnas.162241099 . 2002PNAS...9911754E . free .
2. Web site: Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3.