SRD5A3 explained

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.^{[1] [2]} It is one of three forms of 5α-reductase.

See also

• SRD5A3-CDG
• Congenital disorder of glycosylation
• Kahrizi syndrome, a syndrome caused by a mutation in this gene

Further reading

• Payne AH, Hales DB . Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. . Endocr. Rev. . 25 . 6 . 947–70 . 2004 . 15583024 . 10.1210/er.2003-0030 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Cantagrel V, Lefeber DJ, Ng BG, etal . SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. . Cell . 142 . 2 . 203–17 . 2010 . 20637498 . 10.1016/j.cell.2010.06.001 . 2940322.
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .

Notes and References

1. Web site: Entrez Gene: steroid 5 alpha-reductase 3.
2. Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H . Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer . Cancer Sci. . 99 . 1 . 81–6 . January 2008 . 17986282 . 10.1111/j.1349-7006.2007.00656.x . 51733620 . free . 11158902 .