SRCAP explained

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.^{[1] [2] [3]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Ghosh AK, Majumder M, Steele R, etal . Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. . J. Biol. Chem. . 275 . 10 . 7184–8 . 2000 . 10702287 . 10.1074/jbc.275.10.7184 . free .
• Xu X, Chackalaparampil I, Monroy MA, etal . Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. . J. Virol. . 75 . 21 . 10033–40 . 2001 . 11581372 . 10.1128/JVI.75.21.10033-10040.2001 . 114578 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Monroy MA, Schott NM, Cox L, etal . SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. . Mol. Endocrinol. . 17 . 12 . 2519–28 . 2004 . 14500758 . 10.1210/me.2003-0208 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Cai Y, Jin J, Florens L, etal . The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. . J. Biol. Chem. . 280 . 14 . 13665–70 . 2005 . 15647280 . 10.1074/jbc.M500001200 . free .
• Eissenberg JC, Wong M, Chrivia JC . Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. . Mol. Cell. Biol. . 25 . 15 . 6559–69 . 2005 . 16024792 . 10.1128/MCB.25.15.6559-6569.2005 . 1190335 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Ruhl DD, Jin J, Cai Y, etal . Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. . Biochemistry . 45 . 17 . 5671–7 . 2006 . 16634648 . 10.1021/bi060043d .
• Cai Y, Jin J, Gottschalk AJ, etal . Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. . Methods . 40 . 4 . 312–7 . 2007 . 17101442 . 10.1016/j.ymeth.2006.06.023 . 3092633.
• Wong MM, Cox LK, Chrivia JC . The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. . J. Biol. Chem. . 282 . 36 . 26132–9 . 2007 . 17617668 . 10.1074/jbc.M703418200 . free .

External links

• OMIM entry on Floating-Harbor syndrome and SRCAP

Notes and References

1. Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J . Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein . J Biol Chem . 274 . 23 . 16370–6 . Jul 1999 . 10347196 . 10.1074/jbc.274.23.16370 . free .
2. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 4 . 2 . 141–50 . Sep 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
3. Web site: Entrez Gene: SRCAP Snf2-related CBP activator protein.