SR-57227 explained

SR-57227 is a potent and selective agonist at the 5HT3 receptor, with high selectivity over other serotonin receptor subtypes and good blood–brain barrier penetration.[1] [2] [3] [4]

Notes and References

  1. Bachy A, Héaulme M, Giudice A, Michaud JC, Lefevre IA, Souilhac J, Manara L, Emerit MB, Gozlan H, Hamon M . 6 . SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo . European Journal of Pharmacology . 237 . 2–3 . 299–309 . June 1993 . 7689975 . 10.1016/0014-2999(93)90282-M .
  2. Maksay G, Simonyi M, Bikádi Z . Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists . Journal of Computer-Aided Molecular Design . 18 . 10 . 651–64 . October 2004 . 15849995 . 10.1007/s10822-004-6259-0 . 10510254 .
  3. Yoo JH, Cho JH, Yu HS, Lee KW, Lee BH, Jeong SM, Nah SY, Kim HC, Lee SY, Jang CG . 6 . Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study . Journal of Neurochemistry . 99 . 3 . 976–88 . November 2006 . 16942594 . 10.1111/j.1471-4159.2006.04137.x . 38685481 . free .
  4. Li Y, Raaby KF, Sánchez C, Gulinello M . Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats . Behavioural Brain Research . 256 . 520–8 . November 2013 . 24016840 . 10.1016/j.bbr.2013.09.002 . 45617581 .

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