SR-16435 explained

SR-16435 is a drug which acts as a potent partial agonist at both the μ-opioid receptor and nociceptin receptor. In animal studies it was found to be a potent analgesic, with results suggestive of reduced development of tolerance and increased activity against neuropathic pain compared to classic μ-selective agonists.[1] [2] [3]

See also

Notes and References

  1. Khroyan TV, Zaveri NT, Polgar WE, Orduna J, Olsen C, Jiang F, Toll L . SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice . The Journal of Pharmacology and Experimental Therapeutics . 320 . 2 . 934–43 . February 2007 . 17132815 . 10.1124/jpet.106.111997 . 2920534 .
  2. Spagnolo B, Calo G, Polgar WE, Jiang F, Olsen CM, Berzetei-Gurske I, Khroyan TV, Husbands SM, Lewis JW, Toll L, Zaveri NT . 6 . Activities of mixed NOP and mu-opioid receptor ligands . British Journal of Pharmacology . 153 . 3 . 609–19 . February 2008 . 18059322 . 10.1038/sj.bjp.0707598 . 2241792 .
  3. Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC . Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain . The Journal of Pharmacology and Experimental Therapeutics . 346 . 1 . 11–22 . July 2013 . 23652222 . 10.1124/jpet.113.203984 . 3684842 .

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