SPRY3 explained

Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.^{[1] [2]}

The SPRY3 gene is one of the genes found in the pseudoautosomal regions of the human sex chromosomes (i.e. those 19 genes that are found on both the X and Y chromosome). It is located in the PAR2 region.

Further reading

• Ciccodicola A, D'Esposito M, Esposito T, etal . Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. . Hum. Mol. Genet. . 9 . 3 . 395–401 . 2000 . 10655549 . 10.1093/hmg/9.3.395 . free .
• Lim J, Wong ES, Ong SH, etal . Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. . J. Biol. Chem. . 275 . 42 . 32837–45 . 2000 . 10887178 . 10.1074/jbc.M002156200 . free .
• Lim J, Yusoff P, Wong ES, etal . The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes. . Mol. Cell. Biol. . 22 . 22 . 7953–66 . 2002 . 12391162 . 10.1128/MCB.22.22.7953-7966.2002 . 134720 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Anteby EY, Natanson-Yaron S, Greenfield C, etal . Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. . Placenta . 26 . 6 . 476–83 . 2005 . 15950061 . 10.1016/j.placenta.2004.08.008 .
• De Bonis ML, Cerase A, Matarazzo MR, etal . Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. . Hum. Mol. Genet. . 15 . 7 . 1123–32 . 2006 . 16500999 . 10.1093/hmg/ddl027 . free .
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G . A functional interaction between sprouty proteins and caveolin-1. . J. Biol. Chem. . 281 . 39 . 29201–2912 . 2006 . 16877379 . 10.1074/jbc.M603921200 . free .

Notes and References

1. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA . sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways . Cell . 92 . 2 . 253–63 . Feb 1998 . 9458049 . 10.1016/S0092-8674(00)80919-8 . free .
2. Web site: Entrez Gene: SPRY3 sprouty homolog 3 (Drosophila).