SPRY1 explained

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.^{[1] [2] [3]}

See also

• Neurofibromin 1
• SPRED1

Further reading

• Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR . Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain . The Journal of Biological Chemistry . 275 . 42 . 32837–45 . October 2000 . 10887178 . 10.1074/jbc.M002156200 . free .
• Egan JE, Hall AB, Yatsula BA, Bar-Sagi D . The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins . Proceedings of the National Academy of Sciences of the United States of America . 99 . 9 . 6041–6 . April 2002 . 11983899 . 122898 . 10.1073/pnas.052090899 . 2002PNAS...99.6041E . free .
• Hanafusa H, Torii S, Yasunaga T, Nishida E . Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway . Nature Cell Biology . 4 . 11 . 850–8 . November 2002 . 12402043 . 10.1038/ncb867 . 31064800 .
• Di Y, Li J, Zhang Y, He X, Lu H, Xu D, Ling J, Huo K, Wan D, Li YY, Gu J . 6 . HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins . Journal of Biochemistry . 133 . 6 . 713–8 . June 2003 . 12869526 . 10.1093/jb/mvg091 .
• Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, Yin G, Ye X, Gu S, Xie Y, Mao Y . 6 . Identification and expression analysis of a novel splice variant of human Sprouty1 gene . International Journal of Molecular Medicine . 12 . 5 . 783–7 . November 2003 . 14533010 . 10.3892/ijmm.12.5.783 .
• Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S . Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching . Placenta . 26 . 6 . 476–83 . July 2005 . 15950061 . 10.1016/j.placenta.2004.08.008 .
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G . A functional interaction between sprouty proteins and caveolin-1 . The Journal of Biological Chemistry . 281 . 39 . 29201–12 . September 2006 . 16877379 . 10.1074/jbc.M603921200 . free .
• Fritzsche S, Kenzelmann M, Hoffmann MJ, Müller M, Engers R, Gröne HJ, Schulz WA . Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma . Endocrine-Related Cancer . 13 . 3 . 839–49 . September 2006 . 16954433 . 10.1677/erc.1.01190 . free .
• Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M . Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene . Cancer Research . 70 . 2 . 762–71 . January 2010 . 20068162 . 10.1158/0008-5472.CAN-09-2532 . free .
• Charles NJ, Huebert RC, Lee S, Adhikari N, Polster S, Rider JE, Braunlin E, Mariash A, Robledo M, Schuweiler D, Hall JL . 6 . Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function . Molecular and Cellular Biochemistry . 342 . 1–2 . 57–62 . September 2010 . 20461448 . 2923832 . 10.1007/s11010-010-0468-8 .

Notes and References

1. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA . sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways . Cell . 92 . 2 . 253–63 . January 1998 . 9458049 . 10.1016/S0092-8674(00)80919-8 . 498977 . free .
2. Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I . Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation . EMBO Reports . 6 . 7 . 635–41 . July 2005 . 15962011 . 1369112 . 10.1038/sj.embor.7400453 .
3. Web site: Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila).