SPRR3 explained
Small proline-rich protein 3 is a protein that in humans is encoded by the SPRR3 gene,[1] [2] which is found within the epidermal differentiation complex (EDC).[3]
Further reading
- Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC . The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation . The Journal of Investigative Dermatology . 104 . 2 . 204–10 . February 1995 . 7829876 . 10.1111/1523-1747.ep12612759 . free .
- Robinson PA, Marley JJ, High AS, Hume WJ . Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts . Archives of Oral Biology . 39 . 3 . 251–9 . March 1994 . 8018055 . 10.1016/0003-9969(94)90051-5 .
- Abraham JM, Wang S, Suzuki H, Jiang HY, Rosenblum-Vos LS, Yin J, Meltzer SJ . Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors . Cell Growth & Differentiation . 7 . 7 . 855–60 . July 1996 . 8809402 .
- Steinert PM, Marekov LN . Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope . The Journal of Biological Chemistry . 272 . 3 . 2021–30 . January 1997 . 8999895 . 10.1074/jbc.272.3.2021 . free .
- Steinert PM, Candi E, Kartasova T, Marekov L . Small proline-rich proteins are cross-bridging proteins in the cornified cell envelopes of stratified squamous epithelia . Journal of Structural Biology . 122 . 1–2 . 76–85 . 1998 . 9724607 . 10.1006/jsbi.1998.3957 .
- Fischer DF, Sark MW, Lehtola MM, Gibbs S, van de Putte P, Backendorf C . Structure and evolution of the human SPRR3 gene: implications for function and regulation . Genomics . 55 . 1 . 88–99 . January 1999 . 9889002 . 10.1006/geno.1998.5622 .
- Steinert PM, Candi E, Tarcsa E, Marekov LN, Sette M, Paci M, Ciani B, Guerrieri P, Melino G . Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein . Cell Death and Differentiation . 6 . 9 . 916–30 . September 1999 . 10510474 . 10.1038/sj.cdd.4400568 . free .
- Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3491–6 . March 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . 2000PNAS...97.3491D . free .
- Marenholz I, Zirra M, Fischer DF, Backendorf C, Ziegler A, Mischke D . Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library . Genome Research . 11 . 3 . 341–55 . March 2001 . 11230159 . 311024 . 10.1101/gr.114801 .
- Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C . Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function . The Journal of Biological Chemistry . 276 . 22 . 19231–7 . June 2001 . 11279051 . 10.1074/jbc.M100336200 . free .
- Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi-Agró A, Melino G . Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro . The Journal of Biological Chemistry . 276 . 37 . 35014–23 . September 2001 . 11443109 . 10.1074/jbc.M010157200 . free .
- Smolinski KN, Abraham JM, Souza RF, Yin J, Wang S, Xu Y, Zou TT, Kong D, Fleisher AS, Meltzer SJ . Activation of the esophagin promoter during esophageal epithelial cell differentiation . Genomics . 79 . 6 . 875–80 . June 2002 . 12036303 . 10.1006/geno.2002.6775 .
- Katou F, Shirai N, Kamakura S, Tagami H, Nagura H, Motegi K . Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa . The British Journal of Dermatology . 148 . 5 . 898–905 . May 2003 . 12786819 . 10.1046/j.1365-2133.2003.05288.x . 31095981 .
- Lehr E, Hohl D, Huber M, Brown D . Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3 . Journal of Medical Virology . 72 . 3 . 478–83 . March 2004 . 14748073 . 10.1002/jmv.20011 . 34708572 .
- Palmeri D, Zuo FR, Rosen SD, Hemmerich S . Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking . Journal of Leukocyte Biology . 75 . 5 . 910–27 . May 2004 . 14761935 . 10.1189/jlb.0903408 . free .
- Kimos MC, Wang S, Borkowski A, Yang GY, Yang CS, Perry K, Olaru A, Deacu E, Sterian A, Cottrell J, Papadimitriou J, Sisodia L, Selaru FM, Mori Y, Xu Y, Yin J, Abraham JM, Meltzer SJ . Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression . International Journal of Cancer . 111 . 3 . 415–7 . September 2004 . 15221970 . 10.1002/ijc.20267 . free .
- Hong SH, Nah HY, Lee JY, Lee YJ, Lee JW, Gye MC, Kim CH, Kang BM, Kim MK . Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus . Molecules and Cells . 17 . 3 . 477–84 . June 2004 . 15232223 .
Notes and References
- Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C . Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins . Genomics . 16 . 3 . 630–7 . June 1993 . 8325635 . 10.1006/geno.1993.1240 .
- Web site: Entrez Gene: SPRR3 small proline-rich protein 3.
- Kypriotou M, Huber M, Hohl D . The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family . Experimental Dermatology . 21 . 9 . 643–9 . September 2012 . 22507538 . 10.1111/j.1600-0625.2012.01472.x . free .