SPRED2 explained

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.^[1]

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1^[1]).

Further reading

• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Wakioka T, Sasaki A, Kato R, etal . Spred is a Sprouty-related suppressor of Ras signalling. . Nature . 412 . 6847 . 647–51 . 2001 . 11493923 . 10.1038/35088082 . 2001Natur.412..647W . 4345140 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kato R, Nonami A, Taketomi T, etal . Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. . Biochem. Biophys. Res. Commun. . 302 . 4 . 767–72 . 2003 . 12646235 . 10.1016/S0006-291X(03)00259-6 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Nobuhisa I, Kato R, Inoue H, etal . Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. . J. Exp. Med. . 199 . 5 . 737–42 . 2004 . 14981116 . 10.1084/jem.20030830 . 2213301 .
• Miyoshi K, Wakioka T, Nishinakamura H, etal . The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. . Oncogene . 23 . 33 . 5567–76 . 2004 . 15184877 . 10.1038/sj.onc.1207759 . free .
• Zimmermann J, Jarchau T, Walter U, etal . 1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. . J. Biomol. NMR . 29 . 3 . 435–6 . 2005 . 15213456 . 10.1023/B:JNMR.0000032526.17586.8c . 37933714 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Engelhardt CM, Bundschu K, Messerschmitt M, etal . Expression and subcellular localization of Spred proteins in mouse and human tissues. . Histochem. Cell Biol. . 122 . 6 . 527–38 . 2005 . 15580519 . 10.1007/s00418-004-0725-6 . 24496085 .
• King JA, Straffon AF, D'Abaco GM, etal . Distinct requirements for the Sprouty domain for functional activity of Spred proteins. . Biochem. J. . 388 . Pt 2 . 445–54 . 2005 . 15683364 . 10.1042/BJ20041284 . 1138951 .
• Bundschu K, Knobeloch KP, Ullrich M, etal . Gene disruption of Spred-2 causes dwarfism. . J. Biol. Chem. . 280 . 31 . 28572–80 . 2005 . 15946934 . 10.1074/jbc.M503640200 . free .
• Yoshida T, Hisamoto T, Akiba J, etal . Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. . Oncogene . 25 . 45 . 6056–66 . 2006 . 16652141 . 10.1038/sj.onc.1209635 . free .
• Lock P, I ST, Straffon AF, etal . Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. . Biochem. Biophys. Res. Commun. . 351 . 4 . 1018–23 . 2007 . 17094949 . 10.1016/j.bbrc.2006.10.150 .

External links

• GeneReviews/NIH/NCBI/UW entry on Legius syndrome SPRED1 Sprouty-related, EVH1 domain-containing protein 1

Notes and References

1. Web site: Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2.