SPOCK1 explained

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.^{[1] [2]}

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.

Further reading

• Périn JP, Alliel PM, Jollès P, Bonnet F . Proteoglycans in male reproductive tract . Exs . 70 . 191–7 . 1994 . 7507743 . 10.1007/978-3-0348-7545-5_11. 2024-02-07 . 978-3-0348-7547-9 .
• Charbonnier F, Périn JP, Roussel G, etal . [Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology] . C. R. Séances Soc. Biol. Fil. . 191 . 1 . 127–33 . 1997 . 9181134 .
• Alliel PM, Perin JP, Jollès P, Bonnet FJ . Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. . Eur. J. Biochem. . 214 . 1 . 347–50 . 1993 . 8389704 . 10.1111/j.1432-1033.1993.tb17930.x .
• Bonnet F, Périn JP, Charbonnier F, etal . Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells. . J. Biol. Chem. . 271 . 8 . 4373–80 . 1996 . 8626787 . 10.1074/jbc.271.8.4373 . free.
• Marr HS, Basalamah MA, Edgell CJ . Endothelial cell expression of testican mRNA. . Endothelium . 5 . 3 . 209–19 . 1998 . 9272383 . 10.3109/10623329709053399 .
• Kohfeldt E, Maurer P, Vannahme C, Timpl R . Properties of the extracellular calcium binding module of the proteoglycan testican. . FEBS Lett. . 414 . 3 . 557–61 . 1997 . 9323035 . 10.1016/S0014-5793(97)01070-3 . 25552375 . free .
• Marr HS, Basalamah MA, Bouldin TW, etal . Distribution of testican expression in human brain. . Cell Tissue Res. . 302 . 2 . 139–44 . 2001 . 11131125 . 10.1007/s004410000277 . 9937680 .
• BaSalamah MA, Marr HS, Duncan AW, Edgell CJ . Testican in human blood. . Biochem. Biophys. Res. Commun. . 283 . 5 . 1083–90 . 2001 . 11355883 . 10.1006/bbrc.2001.4900 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nakada M, Miyamori H, Yamashita J, Sato H . Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. . Cancer Res. . 63 . 12 . 3364–9 . 2003 . 12810672 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Schmutz J, Martin J, Terry A, etal . The DNA sequence and comparative analysis of human chromosome 5. . Nature . 431 . 7006 . 268–74 . 2004 . 15372022 . 10.1038/nature02919 . 2004Natur.431..268S . free .
• Prenzel KL, Warnecke-Eberz U, Xi H, etal . Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater. . Oncol. Rep. . 15 . 5 . 1397–401 . 2006 . 16596217 . 10.3892/or.15.5.1397. free .

Notes and References

1. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM . Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31 . Genomics . 48 . 3 . 377–80 . Jun 1998 . 9545645 . 10.1006/geno.1997.5199 .
2. Web site: Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1.