SPINK2 explained

Serine protease inhibitor Kazal-type 2 also known as acrosin-trypsin inhibitor is a protein that in humans is encoded by the SPINK2 gene.^{[1] [2]}

See also

• Kazal-type serine protease inhibitor domain

References

^[3]

Further reading

• Wapenaar MC, Monsuur AJ, Poell J, etal . The SPINK gene family and celiac disease susceptibility. . Immunogenetics . 59 . 5 . 349–57 . 2007 . 17333166 . 10.1007/s00251-007-0199-5 . 1914236 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rockett JC, Patrizio P, Schmid JE, etal . Gene expression patterns associated with infertility in humans and rodent models. . Mutat. Res. . 549 . 1–2 . 225–40 . 2004 . 15120973 . 10.1016/j.mrfmmm.2003.11.017 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Fink E, Hehlein-Fink C, Eulitz M . Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones. . FEBS Lett. . 270 . 1–2 . 222–4 . 1990 . 2226783 . 10.1016/0014-5793(90)81273-Q . 1068212 .
• Collins J, Taube W, Fink E, etal . Variants of human seminal acrosin inhibitor (HUSI-II) which inhibit human leukocyte elastase. . Biomed. Biochim. Acta . 50 . 4–6 . 683–5 . 1992 . 1801743 .
• Möritz A, Lilja H, Fink E . Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II). . FEBS Lett. . 278 . 1 . 127–30 . 1991 . 1704312 . 10.1016/0014-5793(91)80099-O . 34332531 . free .
• Dietl T, Kruck J, Schill WB, Fritz H . Localization of seminal plasma proteinase inhibitors in human spermatozoa as revealed by the indirect immunofluorescence technique. . Hoppe-Seyler's Z. Physiol. Chem. . 357 . 10 . 1333–7 . 1977 . 791787 . 10.1515/bchm2.1976.357.2.1333.

Notes and References

1. Moritz A, Grzeschik KH, Wingender E, Fink E . Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II) . Gene . 123 . 2 . 277–81 . Mar 1993 . 8428671 . 10.1016/0378-1119(93)90138-S .
2. Web site: Entrez Gene: SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor).
3. 21705336 . 10.1074/jbc.M111.244905 . 286 . 33 . Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes . 3190718 . 2011 . J. Biol. Chem. . 29108–17 . Lee B, Park I, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Cho BN, Eddy EM, Cho C. free .