SPIB explained

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.^{[1] [2]}

Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM]

Interactions

SPIB has been shown to interact with MAPK3^[3] and MAPK8.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F . Differential phosphorylations of Spi-B and Spi-1 transcription factors . Oncogene . 12 . 4 . 863–73 . February 1996 . 8632909 .
• Ray-Gallet D, Tavitian A, Moreau-Gachelin F . An alternatively spliced isoform of the Spi-B transcription factor . Biochemical and Biophysical Research Communications . 223 . 2 . 257–63 . June 1996 . 8670269 . 10.1006/bbrc.1996.0881 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Rao S, Matsumura A, Yoon J, Simon MC . SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1 . The Journal of Biological Chemistry . 274 . 16 . 11115–24 . April 1999 . 10196196 . 10.1074/jbc.274.16.11115 . free .
• Nagy M, Chapuis B, Matthes T . Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells . British Journal of Haematology . 116 . 2 . 429–35 . February 2002 . 11841448 . 10.1046/j.1365-2141.2002.03271.x . 22132659 . free .
• Yamamoto H, Kihara-Negishi F, Yamada T, Suzuki M, Nakano T, Oikawa T . Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb . Cell Growth & Differentiation . 13 . 2 . 69–75 . February 2002 . 11864910 .
• Schotte R, Rissoan MC, Bendriss-Vermare N, Bridon JM, Duhen T, Weijer K, Brière F, Spits H . The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development . Blood . 101 . 3 . 1015–23 . February 2003 . 12393575 . 10.1182/blood-2002-02-0438 . free .
• Schotte R, Nagasawa M, Weijer K, Spits H, Blom B . The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development . The Journal of Experimental Medicine . 200 . 11 . 1503–9 . December 2004 . 15583020 . 2211952 . 10.1084/jem.20041231 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Geng CD, Vedeckis WV . c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter . The Journal of Biological Chemistry . 280 . 52 . 43264–71 . December 2005 . 16263717 . 10.1074/jbc.M508245200 . free .
• Dontje W, Schotte R, Cupedo T, Nagasawa M, Scheeren F, Gimeno R, Spits H, Blom B . Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B . Blood . 107 . 6 . 2446–52 . March 2006 . 16317090 . 10.1182/blood-2005-05-2090 . free .

Notes and References

1. Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F . Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1 . Molecular and Cellular Biology . 12 . 10 . 4297–304 . October 1992 . 1406622 . 360353 . 10.1128/mcb.12.10.4297.
2. Web site: Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related).
3. Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F . Differential phosphorylations of Spi-B and Spi-1 transcription factors . Oncogene . 12 . 4 . 863–73 . February 1996 . 8632909 .