SPDYA explained

Speedy protein A is a protein that in humans is encoded by the SPDYA gene.^{[1] [2] [3] [4]}

Interactions

SPDYA has been shown to interact with CDKN1B.^[5]

Further reading

• Porter LA, Kong-Beltran M, Donoghue DJ . Spy1 interacts with p27Kip1 to allow G1/S progression . Molecular Biology of the Cell . 14 . 9 . 3664–74 . Sep 2003 . 12972555 . 196558 . 10.1091/mbc.E02-12-0820 .
• Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ . Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation . The Journal of Biological Chemistry . 281 . 46 . 35425–35 . Nov 2006 . 16951407 . 10.1074/jbc.M604720200 . free .
• McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ . Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27 . Cell Cycle . 6 . 15 . 1937–45 . Aug 2007 . 17671428 . 10.4161/cc.6.15.4520 . free .

Notes and References

1. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ . Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2 . The Journal of Cell Biology . 157 . 3 . 357–66 . Apr 2002 . 11980914 . 2173287 . 10.1083/jcb.200109045 .
2. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ . Human Spy1 promotes survival of mammalian cells following DNA damage . Cancer Research . 63 . 13 . 3701–7 . Jul 2003 . 12839962 .
3. Cheng A, Xiong W, Ferrell JE, Solomon MJ . Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins . Cell Cycle . 4 . 1 . 155–65 . Jan 2005 . 15611625 . 10.4161/cc.4.1.1347 . free .
4. Web site: Entrez Gene: SPDYA speedy homolog A (Drosophila).
5. Porter LA, Kong-Beltran M, Donoghue DJ . Spy1 interacts with p27Kip1 to allow G1/S progression . Molecular Biology of the Cell . 14 . 9 . 3664–74 . Sep 2003 . 12972555 . 196558 . 10.1091/mbc.E02-12-0820 .