SPARCL1 explained

SPARC-like protein 1 (SPARCL1 or SC1), also known as hevin (short for high endothelial venule protein), is a secreted protein with high structural similarity to SPARC.^{[1] [2]} It interacts with the extracellular matrix to create intermediate states of cell adhesion.^[3] Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein.^{[4] [5]} In humans hevin is encoded by the SPARCL1 gene.^{[6] [7]}

Interactions

• CALY (calcyon)^[8]

See also

• Thrombospondin
• Tenascin

References

Further reading

• Girard JP, Springer TA . Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules . The Journal of Biological Chemistry . 271 . 8 . 4511–7 . February 1996 . 8626806 . 10.1074/jbc.271.8.4511 . free .
• Claeskens A, Ongenae N, Neefs JM, Cheyns P, Kaijen P, Cools M, Kutoh E . Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation . British Journal of Cancer . 82 . 6 . 1123–30 . March 2000 . 10735494 . 2363342 . 10.1054/bjoc.1999.1051 .
• Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA . 6 . Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues . Nature Biotechnology . 22 . 6 . 724–31 . June 2004 . 15146195 . 10.1038/nbt969 . 36630738 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . 6 . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Li Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M . Interaction of myocilin with the C-terminal region of hevin . Biochemical and Biophysical Research Communications . 339 . 3 . 797–804 . January 2006 . 16316624 . 10.1016/j.bbrc.2005.11.082 .
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry . Journal of Proteome Research . 4 . 6 . 2070–80 . 2006 . 16335952 . 1850943 . 10.1021/pr0502065 .
• Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, Venturelli E, Cortini F, Piola M, Villa C, Naldi P, Monaco F, Bresolin N, Galimberti D . 6 . Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis . Neuroscience Letters . 425 . 3 . 173–6 . October 2007 . 17825989 . 10.1016/j.neulet.2007.08.020 . 9381979 .

Notes and References

1. Girard JP, Springer TA . Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC . Immunity . 2 . 1 . 113–23 . January 1995 . 7600298 . 10.1016/1074-7613(95)90083-7 . free .
2. Hambrock HO, Nitsche DP, Hansen U, Bruckner P, Paulsson M, Maurer P, Hartmann U . SC1/hevin. An extracellular calcium-modulated protein that binds collagen I . The Journal of Biological Chemistry . 278 . 13 . 11351–8 . March 2003 . 12538579 . 10.1074/jbc.M212291200 . free .
3. Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, Sanders J, Starcher B, Wight TN, Puolakkainen P, Sage EH . 6 . Matricellular hevin regulates decorin production and collagen assembly . The Journal of Biological Chemistry . 281 . 37 . 27621–32 . September 2006 . 16844696 . 10.1074/jbc.M510507200 . free .
4. Morris AH, Kyriakides TR . Matricellular proteins and biomaterials . Matrix Biology . 37 . 183–91 . July 2014 . 24657843 . 4167162 . 10.1016/j.matbio.2014.03.002 .
5. Sullivan MM, Sage EH . Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family . The International Journal of Biochemistry & Cell Biology . 36 . 6 . 991–6 . June 2004 . 15094114 . 10.1016/j.biocel.2004.01.017 .
6. Schraml P, Shipman R, Stulz P, Ludwig CU . cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST) . Trends in Genetics . 9 . 3 . 70–1 . March 1993 . 8488563 . 10.1016/0168-9525(93)90216-5 .
7. Web site: Entrez Gene: SPARCL1 SPARC-like 1 (mast9, hevin).
8. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, Han J, Jung JH, Lee J, Ryu H, Park JY, Hwang EM, Suk K . 6 . Hevin-calcyon interaction promotes synaptic reorganization after brain injury . Cell Death and Differentiation . March 2021 . 28 . 9 . 2571–2588 . 33753902 . 10.1038/s41418-021-00772-5 . 8408247 . 1350-9047 . free .