Sp4 transcription factor explained

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.^{[1] [2]}

Interactions

Sp4 transcription factor has been shown to interact with E2F1.^[3]

Further reading

• Suske G . The Sp-family of transcription factors . Gene . 238 . 2 . 291–300 . Oct 1999 . 10570957 . 10.1016/S0378-1119(99)00357-1 .
• Hagen G, Dennig J, Preiss A, Beato M, Suske G . Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3 . The Journal of Biological Chemistry . 270 . 42 . 24989–94 . Oct 1995 . 7559627 . 10.1074/jbc.270.42.24989 . free .
• Kalff-Suske M, Kunz J, Grzeschik KH, Suske G . Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15 . Genomics . 26 . 3 . 631–3 . Apr 1995 . 7607696 . 10.1016/0888-7543(95)80191-N .
• Majello B, De Luca P, Hagen G, Suske G, Lania L . Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1 . Nucleic Acids Research . 22 . 23 . 4914–21 . Nov 1994 . 7800480 . 523756 . 10.1093/nar/22.23.4914 .
• Rotheneder H, Geymayer S, Haidweger E . Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter . Journal of Molecular Biology . 293 . 5 . 1005–15 . Nov 1999 . 10547281 . 10.1006/jmbi.1999.3213 .
• Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR . A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages . Cell . 102 . 5 . 671–82 . Sep 2000 . 11007485 . 10.1016/S0092-8674(00)00089-1 . 3017990 . free .
• Lerner LE, Gribanova YE, Ji M, Knox BE, Farber DB . Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements . The Journal of Biological Chemistry . 276 . 37 . 34999–5007 . Sep 2001 . 11438531 . 10.1074/jbc.M103301200 . free .
• Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB . The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX . The Journal of Biological Chemistry . 277 . 29 . 25877–83 . Jul 2002 . 11943774 . 10.1074/jbc.M201407200 . free .
• Lee DK, Suh D, Edenberg HJ, Hur MW . POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1 . The Journal of Biological Chemistry . 277 . 30 . 26761–8 . Jul 2002 . 12004059 . 10.1074/jbc.M202078200 . free .
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts . Molecular Vision . 8 . 196–204 . Jun 2002 . 12107411 .
• Davis W, Chen ZJ, Ile KE, Tew KD . Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors . Nucleic Acids Research . 31 . 3 . 1097–107 . Feb 2003 . 12560508 . 149212 . 10.1093/nar/gkg192 .
• Hong J, Samudio I, Liu S, Abdelrahim M, Safe S . Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins . Endocrinology . 145 . 12 . 5774–85 . Dec 2004 . 15345676 . 10.1210/en.2004-0686 . free .
• Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN . Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases . The Journal of Clinical Endocrinology and Metabolism . 90 . 6 . 3479–90 . Jun 2005 . 15788387 . 10.1210/jc.2004-1962 . free .
• Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S . Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins . Endocrinology . 147 . 7 . 3285–95 . Jul 2006 . 16574784 . 10.1210/en.2006-0081 .
• Gao YQ, Danciger M, Ozgul RK, Gribanova Y, Jacobson S, Farber DB . Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease . Molecular Vision . 13 . 287–92 . 2007 . 17356515 . 2633482 .

Notes and References

1. Hagen G, Müller S, Beato M, Suske G . Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes . Nucleic Acids Research . 20 . 21 . 5519–25 . Nov 1992 . 1454515 . 334381 . 10.1093/nar/20.21.5519 .
2. Web site: Entrez Gene: SP4 Sp4 transcription factor.
3. Rotheneder H, Geymayer S, Haidweger E . Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter . Journal of Molecular Biology . 293 . 5 . 1005–15 . Nov 1999 . 10547281 . 10.1006/jmbi.1999.3213 .