SOS box explained

SOS box is the operator to which the LexA repressor binds to repress the transcription of SOS-induced proteins. SOS boxes are found near the promoter of various genes.[1]

LexA binds to an SOS box in the absence of DNA damage. In the presence of DNA damage the binding of LexA is inactivated by the RecA activator. SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism.[2] Furthermore, SOS boxes may be present in a dual fashion, which indicates that more than one SOS box can be within the same promoter.[3]

Examples

! Phylogenetic Clade! Sequence! Reference
AlphaproteobacteriaGAAC(N)7GAAC
GTTC(N)7GTTC		[4] [5]
Betaproteobacteria
Gammaproteobacteria		CTGT(N)8ACAG[6]
DeltaproteobacteriaCTRHAMRYBYGTTCAGS[7]
Gram-positive bacteriaCGAACRNRYGTTYC[8] [9]
CyanobacteriaRGTAC(N)3DGTWCB[10]
See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters.

See also

Notes and References

  1. Book: Henkin . Tina M. . Peters . Joseph E. . Snyder and Champness molecular genetics of bacteria . 2020 . John Wiley & Sons, Inc. . Hoboken, NJ : Washington, D.C . 9781555819750 . 409 . Fifth.
  2. Walker . Graham C. . SOS-regulated proteins in translesion DNA synthesis and mutagenesis . Trends in Biochemical Sciences . October 1995 . 20 . 10 . 416–20 . 8533155 . 10.1016/s0968-0004(00)89091-x.
  3. Gillor . Osnat . Vriezen . Jan A. C.. Riley . Margaret A. . The role of SOS boxes in enteric bacteriocin regulation . Microbiology . Jun 2008 . 154 . 6 . 10.1099/mic.0.2007/016139-0 . 18524933 . 2729051 . 1783–1792 . free.
  4. Fernández de Henestrosa . Antonio R. . Rivera . Eusebi . Tapias . Angels . Barbé . Jordi . Identification of the Rhodobacter sphaeroides SOS box . Molecular Microbiology . June 1998 . 28 . 5 . 991–1003 . 10.1046/j.1365-2958.1998.00860.x . 9663685 . free.
  5. Tapias . A. . Barbé . J. . Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti . Molecular and General Genetics MGG . August 1999 . 262 . 1 . 121–130 . 10.1007/s004380051066 . 10503543 . 2373618.
  6. Erill . Ivan . Escribano . Marcos . Campoy . Susana . Barbé . Jordi . In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon . Bioinformatics . 22 November 2003 . 19 . 17 . 2225–2236 . 10.1093/bioinformatics/btg303 . 14630651 . free.
  7. Campoy . Susana . Fontes . Marta . Padmanabhan . S. . Cortés . Pilar . Llagostera . Montserrat . Barbé . Jordi . LexA‐independent DNA damage‐mediated induction of gene expression in Myxococcus xanthus . Molecular Microbiology . August 2003 . 49 . 3 . 769–781 . 10.1046/j.1365-2958.2003.03592.x . 12864858 .
  8. Winterling . Kevin W. . Chafin . David . Hayes . Jeffery J. . Sun . Ji . Levine . Arthur S. . Yasbin . Ronald E. . Woodgate . Roger . The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence . Journal of Bacteriology . 15 April 1998 . 180 . 8 . 2201–2211 . 10.1128/JB.180.8.2201-2211.1998 . 9555905 . 107149.
  9. Davis . Elaine O. . Dullaghan . Edith M. . Rand . Lucinda . Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis . Journal of Bacteriology . 15 June 2002 . 184 . 12 . 3287–3295 . 10.1128/JB.184.12.3287-3295.2002 . 12029045 . 135081.
  10. Mazón . G. . Lucena . J. M. . Campoy . S. . Fernández de Henestrosa . A. R. . Candau . P. . Barbé . J. . LexA-binding sequences in Gram-positive and cyanobacteria are closely related . Molecular Genetics and Genomics . February 2004 . 271 . 1 . 40–49 . 10.1007/s00438-003-0952-x . 14652736 . 9219764.

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