SORBS3 explained

Vinexin is a protein that in humans is encoded by the SORBS3 gene.^{[1] [2] [3]}

Interactions

SORBS3 has been shown to interact with DLG5^[4] and MAPK1.^[5]

Further reading

• Akamatsu M, Aota S, Suwa A, etal . Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. . J. Biol. Chem. . 274 . 50 . 35933–7 . 2000 . 10585480 . 10.1074/jbc.274.50.35933 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wakabayashi M, Ito T, Mitsushima M, etal . Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. . J. Biol. Chem. . 278 . 24 . 21709–14 . 2003 . 12657639 . 10.1074/jbc.M211004200 . free .
• Townson SM, Dobrzycka KM, Lee AV, etal . SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. . J. Biol. Chem. . 278 . 22 . 20059–68 . 2003 . 12660241 . 10.1074/jbc.M212988200 . free .
• Mitsushima M, Suwa A, Amachi T, etal . Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. . J. Biol. Chem. . 279 . 33 . 34570–7 . 2004 . 15184391 . 10.1074/jbc.M402304200 . free .
• Martens N, Wery M, Wang P, etal . The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. . Exp. Cell Res. . 298 . 1 . 239–48 . 2004 . 15242778 . 10.1016/j.yexcr.2004.04.002 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bour G, Plassat JL, Bauer A, etal . Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. . J. Biol. Chem. . 280 . 17 . 17027–37 . 2005 . 15734736 . 10.1074/jbc.M501344200 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Mitsushima M . Ueda K . Kioka N . Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. . Genes Cells . 11 . 9 . 971–82 . 2006 . 16923119 . 10.1111/j.1365-2443.2006.00995.x . 24238810 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Mizutani K, Ito H, Iwamoto I, etal . Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth. . Oncogene . 26 . 50 . 7122–31 . 2007 . 17486060 . 10.1038/sj.onc.1210512 . 9284621 . 20.500.12099/23093 . free .

Notes and References

1. Kioka N . Sakata S . Kawauchi T . Amachi T . Akiyama SK . Okazaki K . Yaen C . Yamada KM . Aota S . Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization . J Cell Biol . 144 . 1 . 59–69 . Mar 1999 . 9885244 . 2148117 . 10.1083/jcb.144.1.59 .
2. Kioka N . [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2] . Seikagaku . 74 . 11 . 1356–60 . Jan 2003 . 12510380 .
3. Web site: Entrez Gene: SORBS3 sorbin and SH3 domain containing 3.
4. Wakabayashi . Makoto . Ito Takuya . Mitsushima Masaru . Aizawa Sanae . Ueda Kazumitsu . Amachi Teruo . Kioka Noriyuki . Jun 2003 . Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact . J. Biol. Chem. . 278 . 24 . 21709–14 . 0021-9258. 12657639 . 10.1074/jbc.M211004200 . free .
5. Mitsushima . Masaru . Suwa Akira . Amachi Teruo . Ueda Kazumitsu . Kioka Noriyuki . Aug 2004 . Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin . J. Biol. Chem. . 279 . 33 . 34570–7 . 0021-9258. 15184391 . 10.1074/jbc.M402304200 . free .