SOCS6 explained

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.^{[1] [2] [3]}

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.^[4]

Further reading

• Kile BT, Schulman BA, Alexander WS, etal . The SOCS box: a tale of destruction and degradation. . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 .
• Mooney RA, Senn J, Cameron S, etal . Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. . J. Biol. Chem. . 276 . 28 . 25889–93 . 2001 . 11342531 . 10.1074/jbc.M010579200 . free .
• Krebs DL, Uren RT, Metcalf D, etal . SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. . Mol. Cell. Biol. . 22 . 13 . 4567–78 . 2002 . 12052866 . 10.1128/MCB.22.13.4567-4578.2002 . 133908 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bayle J, Letard S, Frank R, etal . Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. . J. Biol. Chem. . 279 . 13 . 12249–59 . 2004 . 14707129 . 10.1074/jbc.M313381200 . free .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Bayle J, Lopez S, Iwaï K, etal . The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. . FEBS Lett. . 580 . 11 . 2609–14 . 2006 . 16643902 . 10.1016/j.febslet.2006.03.093 . 44648698 . free .
• Hwang MN, Ha TH, Park J, etal . Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation. . Biochem. Biophys. Res. Commun. . 354 . 1 . 184–9 . 2007 . 17210122 . 10.1016/j.bbrc.2006.12.175 .
• Hwang MN, Min CH, Kim HS, etal . The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels. . Biochem. Biophys. Res. Commun. . 360 . 2 . 333–8 . 2007 . 17603019 . 10.1016/j.bbrc.2007.06.062 .

Notes and References

1. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A . Cloning and characterization of novel CIS family genes . Biochem Biophys Res Commun . 239 . 2 . 439–46 . Nov 1997 . 9344848 . 10.1006/bbrc.1997.7484 .
2. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res . 10 . 10 . 1546–60 . Nov 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
3. Web site: Entrez Gene: SOCS6 suppressor of cytokine signaling 6.
4. Web site: Entrez Gene: SOCS6 suppressor of cytokine signaling 6.