SNX9 explained

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.^{[1] [2] [3]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.^[4]

Interactions

SNX9 has been shown to interact with ADAM9, DNM2^[5] and ADAM15.^[1]

Further reading

• Teasdale RD, Loci D, Houghton F, etal . A large family of endosome-localized proteins related to sorting nexin 1. . Biochem. J. . 358 . Pt 1 . 7–16 . 2001 . 11485546 . 10.1042/0264-6021:3580007 . 1222026 .
• Lin Q . Lo CG . Cerione RA . Yang W . The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. . J. Biol. Chem. . 277 . 12 . 10134–8 . 2002 . 11799118 . 10.1074/jbc.M110329200 . free .
• Lundmark R . Carlsson SR . The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2. . Biochem. J. . 362 . Pt 3 . 597–607 . 2002 . 11879186 . 10.1042/0264-6021:3620597 . 1222423 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lundmark R . Carlsson SR . Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. . J. Biol. Chem. . 278 . 47 . 46772–81 . 2004 . 12952949 . 10.1074/jbc.M307334200 . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . free . 2003Natur.425..805M .
• Schulze WX . Mann M . A novel proteomic screen for peptide-protein interactions. . J. Biol. Chem. . 279 . 11 . 10756–64 . 2004 . 14679214 . 10.1074/jbc.M309909200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lehner B . Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Lundmark R . Carlsson SR . Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. . J. Biol. Chem. . 279 . 41 . 42694–702 . 2004 . 15299020 . 10.1074/jbc.M407430200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Soulet F . Yarar D . Leonard M . Schmid SL . SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. . Mol. Biol. Cell . 16 . 4 . 2058–67 . 2005 . 15703209 . 10.1091/mbc.E04-11-1016. 1073683 .
• Yeow-Fong L . Lim L . Manser E . SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. . FEBS Lett. . 579 . 22 . 5040–8 . 2005 . 16137687 . 10.1016/j.febslet.2005.07.093 . 44482842 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Childress C . Lin Q . Yang W . Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. . Biochem. J. . 394 . Pt 3 . 693–8 . 2006 . 16316319 . 10.1042/BJ20050576 . 1383719 .
• Marchès O, Batchelor M, Shaw RK, etal . EspF of enteropathogenic Escherichia coli binds sorting nexin 9. . J. Bacteriol. . 188 . 8 . 3110–5 . 2006 . 16585770 . 10.1128/JB.188.8.3110-3115.2006 . 1447016 .
• Schmid EM, Ford MG, Burtey A, etal . Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. . PLOS Biol. . 4 . 9 . e262 . 2007 . 16903783 . 10.1371/journal.pbio.0040262 . 1540706 . free .
• Badour K, McGavin MK, Zhang J, etal . Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 5 . 1593–8 . 2007 . 17242350 . 10.1073/pnas.0610543104 . 1785243 . 2007PNAS..104.1593B . free .

Notes and References

1. Howard L . Nelson KK . Maciewicz RA . Blobel CP . Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 . J Biol Chem . 274 . 44 . 31693–9 . Dec 1999 . 10531379 . 10.1074/jbc.274.44.31693 . free .
2. Yarar D . Waterman-Storer CM . Schmid SL . SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis . Dev Cell . 13 . 1 . 43–56 . Jul 2007 . 17609109 . 10.1016/j.devcel.2007.04.014 . free .
3. Web site: Entrez Gene: SNX9 sorting nexin 9.
4. Web site: Entrez Gene: SNX9 sorting nexin 9.
5. Lundmark . Richard . Carlsson Sven R . Nov 2003 . Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components . J. Biol. Chem. . 278 . 47 . 46772–81 . United States. 0021-9258. 12952949 . 10.1074/jbc.M307334200 . free .