SNX5 explained

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.^{[1] [2] [3]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.

Interactions

SNX5 has been shown to interact with FANCA.

Further reading

• Maruyama K. Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138. 1–2. 171–4. 1994. 8125298. 10.1016/0378-1119(94)90802-8.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 200. 1–2. 149–56. 1997. 9373149. 10.1016/S0378-1119(97)00411-3.
• Teasdale RD, Loci D, Houghton F, etal. A large family of endosome-localized proteins related to sorting nexin 1. Biochem. J.. 358. Pt 1. 7–16. 2001. 11485546. 10.1042/0264-6021:3580007. 1222026.
• Deloukas P, Matthews LH, Ashurst J, etal. The DNA sequence and comparative analysis of human chromosome 20. Nature. 414. 6866. 865–71. 2002. 11780052. 10.1038/414865a. 2001Natur.414..865D . free.
• Strausberg RL, Feingold EA, Grouse LH, etal. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A.. 99. 26. 16899–903. 2003. 12477932. 10.1073/pnas.242603899. 139241. 2002PNAS...9916899M . free.
• Ota T, Suzuki Y, Nishikawa T, etal. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet.. 36. 1. 40–5. 2004. 14702039. 10.1038/ng1285. free.
• Towler MC, Gleeson PA, Hoshino S, etal. Clathrin Isoform CHC22, a Component of Neuromuscular and Myotendinous Junctions, Binds Sorting Nexin 5 and Has Increased Expression during Myogenesis and Muscle Regeneration. Mol. Biol. Cell. 15. 7. 3181–95. 2005. 15133132. 10.1091/mbc.E04-03-0249. 452575.
• Gerhard DS, Wagner L, Feingold EA, etal. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res.. 14. 10B. 2121–7. 2004. 15489334. 10.1101/gr.2596504. 528928.
• Merino-Trigo A, Kerr MC, Houghton F, etal. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. J. Cell Sci.. 117. Pt 26. 6413–24. 2005. 15561769. 10.1242/jcs.01561. 39278533 .
• Rual JF, Venkatesan K, Hao T, etal. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 437. 7062. 1173–8. 2005. 16189514. 10.1038/nature04209. 2005Natur.437.1173R. 4427026.

Notes and References

1. Otsuki T. Kajigaya S. Ozawa K. Liu JM. SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. Biochem Biophys Res Commun. 265. 3. 630–5. Jan 2000. 10600472. 10.1006/bbrc.1999.1731.
2. Wassmer T. Attar N. Bujny MV. Oakley J. Traer CJ. Cullen PJ. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J Cell Sci. 120. Pt 1. 45–54. Dec 2006. 17148574. 10.1242/jcs.03302. free.
3. Web site: Entrez Gene: SNX5 sorting nexin 5.