SNX3 explained

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.^{[1] [2]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.

Further reading

• Parks WT . Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases . J. Biol. Chem. . 276 . 22 . 19332–9 . 2001 . 11279102 . 10.1074/jbc.M100606200 . vanc. Frank DB . Huff C . 3 . Renfrew Haft . C . Martin . J . Meng . X . De Caestecker . MP . McNally . JG . Reddi . A . free .
• Xu Y . SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P . Nat. Cell Biol. . 3 . 7 . 658–66 . 2001 . 11433298 . 10.1038/35083051 . vanc. Hortsman H . Seet L . 3 . Wong . Siew Heng . Hong . Wanjin . 32893219 .
• Vervoort VS . Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype . J. Med. Genet. . 39 . 12 . 893–9 . 2003 . 12471201 . 10.1136/jmg.39.12.893 . 1757218 . vanc. Viljoen D . Smart R . 3 . Suthers . G . Dupont . BR . Abbott . A . Schwartz . CE .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gevaert K . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . vanc. Goethals M . Martens L . 3 . Van Damme . Jozef . Staes . An . Thomas . Grégoire R. . Vandekerckhove . Joël . 23783563 .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . 2003Natur.425..805M . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Beausoleil SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . vanc. Villén J . Gerber SA . 3 . Rush . John . Gygi . Steven P . 14294292 .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• Kumar RA . Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes . BMC Med. Genet. . 8. 48 . 2007 . 17655765 . 10.1186/1471-2350-8-48 . 1950490 . vanc. Everman DB . Morgan CT . 3 . Slavotinek . Anne . Schwartz . Charles E . Simpson . Elizabeth M . free .

Notes and References

1. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI . Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors . Mol Cell Biol . 18 . 12 . 7278–87 . Dec 1998 . 9819414 . 109309 . 10.1128/mcb.18.12.7278.
2. Web site: Entrez Gene: SNX3 sorting nexin 3.