SNX2 explained

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.^{[1] [2]}

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.

Interactions

SNX2 has been shown to interact with FNBP1.^{[3] [4]}

References

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI . Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes . Molecular Biology of the Cell . 11 . 12 . 4105–16 . Dec 2000 . 11102511 . 15060 . 10.1091/mbc.11.12.4105 .
• Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ . Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases . The Journal of Biological Chemistry . 276 . 22 . 19332–9 . Jun 2001 . 11279102 . 10.1074/jbc.M100606200 . free .
• Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A . The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia . Proceedings of the National Academy of Sciences of the United States of America . 98 . 15 . 8756–61 . Jul 2001 . 11438682 . 37508 . 10.1073/pnas.121433898 . 2001PNAS...98.8756F . free .
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA . A large family of endosome-localized proteins related to sorting nexin 1 . The Biochemical Journal . 358 . Pt 1 . 7–16 . Aug 2001 . 11485546 . 1222026 . 10.1042/0264-6021:3580007 .
• Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A . The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance . FEBS Letters . 554 . 1–2 . 10–6 . Nov 2003 . 14596906 . 10.1016/S0014-5793(03)01063-9 . 19552309 .
• Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J . A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking . Molecular Biology of the Cell . 15 . 5 . 2143–55 . May 2004 . 14978220 . 404011 . 10.1091/mbc.E03-09-0711 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW . Novel interaction partners of the TPR/MET tyrosine kinase . FASEB Journal . 19 . 2 . 267–9 . Feb 2005 . 15546961 . 10.1096/fj.04-1558fje . free . 17142907 .
• Abdul-Ghani M, Hartman KL, Ngsee JK . Abstrakt interacts with and regulates the expression of sorting nexin-2 . Journal of Cellular Physiology . 204 . 1 . 210–8 . Jul 2005 . 15690390 . 2963638 . 10.1002/jcp.20285 .
• Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ . Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport . Journal of Cell Science . 118 . Pt 19 . 4527–39 . Oct 2005 . 16179610 . 1904489 . 10.1242/jcs.02568 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Rojas R, Kametaka S, Haft CR, Bonifacino JS . Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors . Molecular and Cellular Biology . 27 . 3 . 1112–24 . Feb 2007 . 17101778 . 1800681 . 10.1128/MCB.00156-06 .
• Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K . Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins . Traffic . 8 . 3 . 297–309 . Mar 2007 . 17319803 . 10.1111/j.1600-0854.2006.00527.x . 10852/11339 . 21600584 . free .

Notes and References

1. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI . Identification of a family of sorting nexin molecules and characterization of their association with receptors . Molecular and Cellular Biology . 18 . 12 . 7278–87 . Dec 1998 . 9819414 . 109309 . 10.1128/mcb.18.12.7278.
2. Web site: Entrez Gene: SNX2 sorting nexin 2.
3. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A . The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance . FEBS Letters . 554 . 1–2 . 10–6 . Nov 2003 . 14596906 . 10.1016/S0014-5793(03)01063-9 . 19552309 .
4. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A . The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia . Proceedings of the National Academy of Sciences of the United States of America . 98 . 15 . 8756–61 . Jul 2001 . 11438682 . 37508 . 10.1073/pnas.121433898 . 2001PNAS...98.8756F . free .