SNAG1 explained
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.[1] [2] [3]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.[4]
Further reading
- Worby CA, Dixon JE . Sorting out the cellular functions of sorting nexins . Nat. Rev. Mol. Cell Biol. . 3 . 12 . 919–31 . 2003 . 12461558 . 10.1038/nrm974 . 36361630 .
- Xu Y, Seet LF, Hanson B, Hong W . The Phox homology (PX) domain, a new player in phosphoinositide signalling . Biochem. J. . 360 . Pt 3 . 513–30 . 2002 . 11736640 . 10.1042/0264-6021:3600513 . 1222253 .
- Ozyildirim AM, Wistow GJ, Gao J, etal . The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts . Invest. Ophthalmol. Vis. Sci. . 46 . 5 . 1572–80 . 2005 . 15851553 . 10.1167/iovs.04-1380 . 10.1.1.123.3574 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Schulze WX, Mann M . A novel proteomic screen for peptide-protein interactions . J. Biol. Chem. . 279 . 11 . 10756–64 . 2004 . 14679214 . 10.1074/jbc.M309909200 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Teasdale RD, Loci D, Houghton F, etal . A large family of endosome-localized proteins related to sorting nexin 1 . Biochem. J. . 358 . Pt 1 . 7–16 . 2001 . 11485546 . 10.1042/0264-6021:3580007 . 1222026 .
Notes and References
- Seet LF, Hong W . The Phox (PX) domain proteins and membrane traffic . Biochim Biophys Acta . 1761 . 8 . 878–96 . Sep 2006 . 16782399 . 10.1016/j.bbalip.2006.04.011 .
- Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J . A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells . FEBS Lett . 581 . 23 . 4455–62 . Sep 2007 . 17761170 . 10.1016/j.febslet.2007.08.025 . 23223511 . free .
- Web site: Entrez Gene: SNAG1 sorting nexin associated golgi protein 1.
- Web site: Entrez Gene: SNAG1 sorting nexin associated golgi protein 1.
