SNX17 explained

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 1 . 5 . 223–9 . 1994 . 7584044 . 10.1093/dnares/1.5.223 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hoja MR, Wahlestedt C, Höög C . A visual intracellular classification strategy for uncharacterized human proteins . Exp. Cell Res. . 259 . 1 . 239–46 . 2000 . 10942595 . 10.1006/excr.2000.4948 .
• Florian V, Schlüter T, Bohnensack R . A new member of the sorting nexin family interacts with the C-terminus of P-selectin . Biochem. Biophys. Res. Commun. . 281 . 4 . 1045–50 . 2001 . 11237770 . 10.1006/bbrc.2001.4467 .
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA . A large family of endosome-localized proteins related to sorting nexin 1 . Biochem. J. . 358 . Pt 1 . 7–16 . 2001 . 11485546 . 1222026 . 10.1042/0264-6021:3580007 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Burden JJ, Sun XM, García AB, Soutar AK . Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17 . J. Biol. Chem. . 279 . 16 . 16237–45 . 2004 . 14739284 . 10.1074/jbc.M313689200 . free .
• Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF . Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin . Mol. Biol. Cell . 15 . 7 . 3095–105 . 2004 . 15121882 . 452567 . 10.1091/mbc.E04-02-0143 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G . Sorting nexin 17 facilitates LRP recycling in the early endosome . EMBO J. . 24 . 16 . 2851–61 . 2005 . 16052210 . 1187941 . 10.1038/sj.emboj.7600756 .
• Czubayko M, Knauth P, Schlüter T, Florian V, Bohnensack R . Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1 . Biochem. Biophys. Res. Commun. . 345 . 3 . 1264–72 . 2006 . 16712798 . 10.1016/j.bbrc.2006.04.129 .

Notes and References

1. Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J . The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor . EMBO J. . 21 . 16 . 4259–67 . Aug 2002 . 12169628 . 126172 . 10.1093/emboj/cdf435 .
2. Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R . Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking . J. Mol. Biol. . 347 . 4 . 813–25 . Mar 2005 . 15769472 . 10.1016/j.jmb.2005.02.004 .
3. Web site: Entrez Gene: SNX17 sorting nexin 17.