SNTG1 explained

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.^{[1] [2]}

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Hogan A, Shepherd L, Chabot J, etal . Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. . J. Biol. Chem. . 276 . 28 . 26526–33 . 2001 . 11352924 . 10.1074/jbc.M104156200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Widberg CH, Bryant NJ, Girotti M, etal . Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. . J. Biol. Chem. . 278 . 37 . 35093–101 . 2003 . 12832401 . 10.1074/jbc.M304261200 . free .
• Buxton P, Zhang XM, Walsh B, etal . Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. . Biochem. J. . 375 . Pt 2 . 433–40 . 2004 . 12877659 . 10.1042/BJ20030427 . 1223698 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Chen Z, Hague C, Hall RA, Minneman KP . Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. . J. Biol. Chem. . 281 . 18 . 12414–20 . 2006 . 16533813 . 10.1074/jbc.M508651200 . free .

Notes and References

1. Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V . Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells . J Biol Chem . 275 . 21 . 15851–60 . Jun 2000 . 10747910 . 10.1074/jbc.M000439200 . free .
2. Web site: Entrez Gene: SNTG1 syntrophin, gamma 1.