SNRPB2 explained

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.^{[1] [2]}

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.^[3]

Further reading

• Feeney RJ, Zieve GW . Nuclear exchange of the U1 and U2 snRNP-specific proteins. . J. Cell Biol. . 110 . 4 . 871–81 . 1990 . 2139037 . 10.1083/jcb.110.4.871 . 2116108 .
• Laitinen J, Saris P, Hölttä E, Pettersson I . U2-snRNP B" protein gene is an early growth-inducible gene. . J. Cell. Biochem. . 58 . 4 . 490–8 . 1995 . 7593271 . 10.1002/jcb.240580412 . 24548645 .
• Hong W, Bennett M, Xiao Y, etal . Association of U2 snRNP with the spliceosomal complex E. . Nucleic Acids Res. . 25 . 2 . 354–61 . 1997 . 9016565 . 10.1093/nar/25.2.354 . 146436 .
• Liu Q, Fischer U, Wang F, Dreyfuss G . The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. . Cell . 90 . 6 . 1013–21 . 1997 . 9323129 . 10.1016/S0092-8674(00)80367-0 . 10855404 . free .
• Moraitou M, Patrinou-Georgoula M, Guialis A . Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. . Biochem. J. . 332 . 1 . 135–44 . 1998 . 9576861 . 10.1042/bj3320135 . 1219461 .
• Price SR, Evans PR, Nagai K . Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. . Nature . 394 . 6694 . 645–50 . 1998 . 9716128 . 10.1038/29234 . 1998Natur.394..645P . 204999419 .
• Neubauer G, King A, Rappsilber J, etal . Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. . Nat. Genet. . 20 . 1 . 46–50 . 1998 . 9731529 . 10.1038/1700 . 585778 .
• Bühler D, Raker V, Lührmann R, Fischer U . Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. . Hum. Mol. Genet. . 8 . 13 . 2351–7 . 2000 . 10556282 . 10.1093/hmg/8.13.2351 . free .
• Pellizzoni L, Charroux B, Rappsilber J, etal . A functional interaction between the survival motor neuron complex and RNA polymerase II. . J. Cell Biol. . 152 . 1 . 75–85 . 2001 . 11149922 . 10.1083/jcb.152.1.75 . 2193649 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Fong YW, Zhou Q . Stimulatory effect of splicing factors on transcriptional elongation. . Nature . 414 . 6866 . 929–33 . 2002 . 11780068 . 10.1038/414929a . 1518837 .
• Jurica MS, Licklider LJ, Gygi SR, etal . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 .
• Chung S, Zhou Z, Huddleston KA, etal . Crooked neck is a component of the human spliceosome and implicated in the splicing process. . Biochim. Biophys. Acta . 1576 . 3 . 287–97 . 2002 . 12084575 . 10.1016/S0167-4781(02)00368-8.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ . Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen . Proc Natl Acad Sci U S A . 84 . 8 . 2421–5 . May 1987 . 2951739 . 304663 . 10.1073/pnas.84.8.2421 . 1987PNAS...84.2421H . free .
2. Web site: Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B.
3. Web site: Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B.