SNRPA1 explained

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^{[1] [2]}

Interactions

SNRPA1 has been shown to interact with CDC5L.^[3]

Further reading

• Ohno M, Kataoka N, Shimura Y . A nuclear cap binding protein from HeLa cells . Nucleic Acids Research . 18 . 23 . 6989–95 . December 1990 . 2148205 . 332760 . 10.1093/nar/18.23.6989 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kjems J, Sharp PA . The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly . Journal of Virology . 67 . 8 . 4769–76 . August 1993 . 10.1128/JVI.67.8.4769-4776.1993 . 8331728 . 237863 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA . A coactivator of pre-mRNA splicing . Genes & Development . 12 . 7 . 996–1009 . April 1998 . 9531537 . 316672 . 10.1101/gad.12.7.996 .
• Price SR, Evans PR, Nagai K . Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA . Nature . 394 . 6694 . 645–50 . August 1998 . 9716128 . 10.1038/29234 . 1998Natur.394..645P . 204999419 .
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M . 6 . Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex . Nature Genetics . 20 . 1 . 46–50 . September 1998 . 9731529 . 10.1038/1700 . 585778 .
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ . The SRm160/300 splicing coactivator is required for exon-enhancer function . Proceedings of the National Academy of Sciences of the United States of America . 96 . 11 . 6125–30 . May 1999 . 10339552 . 26846 . 10.1073/pnas.96.11.6125 . 1999PNAS...96.6125E . free .
• Lundin M, Mikkelsen B, Gudim M, Syed M . Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed . Marine Biotechnology . 2 . 2 . 204–211 . March 2000 . 10811961 . 10.1007/s101269900015 . 20060370 .
• Fong YW, Zhou Q . Stimulatory effect of splicing factors on transcriptional elongation . Nature . 414 . 6866 . 929–33 . 2002 . 11780068 . 10.1038/414929a . 1518837 .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . 6 . Directed proteomic analysis of the human nucleolus . Current Biology . 12 . 1 . 1–11 . January 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . free .
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . April 2002 . 11991638 . 1370266 . 10.1017/S1355838202021088 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . January 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ . Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein . Nucleic Acids Research . 17 . 5 . 1893–906 . March 1989 . 2928112 . 317531 . 10.1093/nar/17.5.1893 .
2. Web site: Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'.
3. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–81 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .