SNIP1 explained

Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.^{[1] [2] [3]}

Interactions

SNIP1 has been shown to interact with EP300.

Further reading

• Kim RH, Flanders KC, Birkey Reffey S, Anderson LA, Duckett CS, Perkins ND, Roberts AB . SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators . J. Biol. Chem. . 276 . 49 . 46297–46304 . 2001 . 11567019 . 10.1074/jbc.M103819200 . free .
• Lin Y, Martin J, Gruendler C, Farley J, Meng X, Li BY, Lechleider R, Huff C, Kim RH, Grasser WA, Paralkar V, Wang T . A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs) . BMC Cell Biol. . 3 . 15 . 2002 . 12097147 . 117437 . 10.1186/1471-2121-3-15 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–1332 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Cui Q, Lim SK, Zhao B, Hoffmann FM . Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP . Oncogene . 24 . 24 . 3864–3874 . 2005 . 15750622 . 10.1038/sj.onc.1208556 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB . SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes . Mol. Cell . 24 . 5 . 771–783 . 2006 . 17157259 . 10.1016/j.molcel.2006.11.006 . free .

Notes and References

1. Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB . A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction . Genes Dev. . 14 . 13 . 1605–16 . 2000 . 10887155 . 316742 . 10.1101/gad.14.13.1605 .
2. Roche KC, Wiechens N, Owen-Hughes T, Perkins ND . The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression . Oncogene . 23 . 50 . 8185–8195 . 2004 . 15378006 . 10.1038/sj.onc.1208025 . free .
3. Web site: Entrez Gene: SNIP1 Smad nuclear interacting protein 1.