SNAP29 explained

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.^{[1] [2] [3]}

Function

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.

Interactions

SNAP29 has been shown to interact with Syntaxin 3 and EHD1.^[4]

SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.^{[5] [6]}

See also

• CEDNIK Syndrome

Further reading

• Wong SH, Xu Y, Zhang T, Griffiths G, Lowe SL, Subramaniam VN, Seow KT, Hong W . GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6 . Mol. Biol. Cell . 10 . 1 . 119–34 . 1999 . 9880331 . 25158 . 10.1091/mbc.10.1.119 .
• Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH . SNAREs contribute to the specificity of membrane fusion . Neuron . 26 . 2 . 457–64 . 2000 . 10839363 . 10.1016/S0896-6273(00)81177-0 . free .
• Rotem-Yehudar R, Galperin E, Horowitz M . Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 . J. Biol. Chem. . 276 . 35 . 33054–60 . 2001 . 11423532 . 10.1074/jbc.M009913200 . free .
• Hohenstein AC, Roche PA . SNAP-29 is a promiscuous syntaxin-binding SNARE . Biochem. Biophys. Res. Commun. . 285 . 2 . 167–71 . 2001 . 11444821 . 10.1006/bbrc.2001.5141 .
• Su Q, Mochida S, Tian JH, Mehta R, Sheng ZH . SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission . Proc. Natl. Acad. Sci. U.S.A. . 98 . 24 . 14038–43 . 2002 . 11707603 . 61163 . 10.1073/pnas.251532398 . free .
• Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T . A dual mechanism controlling the localization and function of exocytic v-SNAREs . Proc. Natl. Acad. Sci. U.S.A. . 100 . 15 . 9011–6 . 2003 . 12853575 . 166429 . 10.1073/pnas.1431910100 . 2003PNAS..100.9011M . free .
• Xu Y, Shi H, Wei S, Wong SH, Hong W . Mutually exclusive interactions of EHD1 with GS32 and syndapin II . Mol. Membr. Biol. . 21 . 4 . 269–77 . 2005 . 15371016 . 10.1080/09687680410001716871 . 22820496 . free .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Pan PY, Cai Q, Lin L, Lu PH, Duan S, Sheng ZH . SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons . J. Biol. Chem. . 280 . 27 . 25769–79 . 2005 . 15890653 . 1864940 . 10.1074/jbc.M502356200 . free .
• Sprecher E, Ishida-Yamamoto A, Mizrahi-Koren M, Rapaport D, Goldsher D, Indelman M, Topaz O, Chefetz I, Keren H, O'brien TJ, Bercovich D, Shalev S, Geiger D, Bergman R, Horowitz M, Mandel H . A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma . Am. J. Hum. Genet. . 77 . 2 . 242–51 . 2005 . 15968592 . 1224527 . 10.1086/432556 .
• Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M . Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 . Cell . 122 . 1 . 33–43 . 2005 . 16009131 . 10.1016/j.cell.2005.05.008 . 16841542 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH . Three novel proteins of the syntaxin/SNAP-25 family . J Biol Chem . 273 . 51 . 34171–9 . January 1999 . 9852078 . 10.1074/jbc.273.51.34171 . free .
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
3. Web site: Entrez Gene: SNAP29 synaptosomal-associated protein, 29kDa.
4. Rotem-Yehudar R, Galperin E, Horowitz M . Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 . J. Biol. Chem. . 276 . 35 . 33054–60 . August 2001 . 11423532 . 10.1074/jbc.M009913200 . free .
5. Mohamud . Yasir . Shi . Junyan . Qu . Junyan . Poon . Tak . Xue . Yuan Chao . Deng . Haoyu . Zhang . Jingchun . Luo . Honglin . 2018-03-20 . Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication . Cell Reports . 22 . 12 . 3292–3303 . 10.1016/j.celrep.2018.02.090 . 2211-1247 . 29562184. free .
6. Corona . Abigail K. . Saulsbery . Holly M. . Corona Velazquez . Angel F. . Jackson . William T. . 2018-03-20 . Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit . Cell Reports . 22 . 12 . 3304–3314 . 10.1016/j.celrep.2018.03.003 . 2211-1247 . 5894509 . 29562185.