SN-22 explained

SN-22 is a chemical compound which acts as a moderately selective agonist at the 5-HT₂ family of serotonin receptors, with a K_i of 19 nM at 5-HT₂ subtypes versus 514 nM at 5-HT_1A receptors.^[1] Many related derivatives are known, most of which are ligands for 5-HT_1A, 5-HT₆ or dopamine D₂ receptors or show SSRI activity.^{[2] [3] [4] [5] [6]}

See also

• BRL-54443
• LY-334370
• LY-367,265
• MPMI
• MPTP
• Naratriptan
• N,N-Dimethyltryptamine
• RU-24969
• Sertindole

Notes and References

1. Taylor EW, Nikam SS, Lambert G, Martin AR, Nelson DL . Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit . Molecular Pharmacology . 34 . 1 . 42–53 . July 1988 . 3393140 .
2. Agarwal A, Pearson PP, Taylor EW, Li HB, Dahlgren T, Herslöf M, Yang Y, Lambert G, Nelson DL, Regan JW . 6 . Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods . Journal of Medicinal Chemistry . 36 . 25 . 4006–14 . December 1993 . 8258822 . 10.1021/jm00077a003 .
3. Cole DC, Ellingboe JW, Lennox WJ, Mazandarani H, Smith DL, Stock JR, Zhang G, Zhou P, Schechter LE . 6 . N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists . Bioorganic & Medicinal Chemistry Letters . 15 . 2 . 379–83 . January 2005 . 15603958 . 10.1016/j.bmcl.2004.10.064 .
4. Deskus JA, Epperson JR, Sloan CP, Cipollina JA, Dextraze P, Qian-Cutrone J, Gao Q, Ma B, Beno BR, Mattson GK, Molski TF, Krause RG, Taber MT, Lodge NJ, Mattson RJ . 6 . Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors . Bioorganic & Medicinal Chemistry Letters . 17 . 11 . 3099–104 . June 2007 . 17391962 . 10.1016/j.bmcl.2007.03.040 .
5. Mattsson C, Andreasson T, Waters N, Sonesson C . Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach . Journal of Medicinal Chemistry . 55 . 22 . 9735–50 . November 2012 . 23043306 . 10.1021/jm300975f .
6. US. 6046215. Inhibition of serotonin reuptake.