SMS (gene) explained

Spermine synthase is an enzyme that in humans is encoded by the SMS gene.^{[1] [2] [3]} The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene encodes a ubiquitous enzyme of polyamine metabolism.^[3]

Further reading

• Snyder RD . Robinson A . Recessive sex-linked mental retardation in the absence of other recognizable abnormalities. Report of a family . Clinical Pediatrics . 8 . 11 . 669–74 . 1969 . 5823961 . 10.1177/000992286900801114 . 32198336 .
• Arena JF, Schwartz C, Ouzts L, etal . X-linked mental retardation with thin habitus, osteoporosis, and kyphoscoliosis: linkage to Xp21.3-p22.12 . Am. J. Med. Genet. . 64 . 1 . 50–8 . 1996 . 8826448 . 10.1002/(SICI)1096-8628(19960712)64:1<50::AID-AJMG7>3.0.CO;2-V .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Cason AL, Ikeguchi Y, Skinner C, etal . X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome . Eur. J. Hum. Genet. . 11 . 12 . 937–44 . 2004 . 14508504 . 10.1038/sj.ejhg.5201072 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .

Notes and References

1. Korhonen VP, Halmekyto M, Kauppinen L, Myohanen S, Wahlfors J, Keinanen T, Hyvonen T, Alhonen L, Eloranta T, Janne J . Molecular cloning of a cDNA encoding human spermine synthase . DNA Cell Biol . 14 . 10 . 841–7 . Nov 1995 . 7546290 . 10.1089/dna.1995.14.841 . Myöhänen .
2. Grieff M . Whyte MP . Thakker RV . Mazzarella R . Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX . Genomics . 44 . 2 . 227–31 . Dec 1997 . 9299240 . 10.1006/geno.1997.4876 .
3. Web site: Entrez Gene: SMS spermine synthase.