SMPD3 explained
Neutral Sphingomyelinase2 is an enzyme that in humans is encoded by the SMPD3 gene.[1] [2]
Further reading
- Chagnon P, Michaud J, Mitchell G, etal . A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. . Am. J. Hum. Genet. . 71 . 6 . 1443–9 . 2003 . 12417987 . 10.1086/344580 . 378590 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Marchesini N, Luberto C, Hannun YA . Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. . J. Biol. Chem. . 278 . 16 . 13775–83 . 2003 . 12566438 . 10.1074/jbc.M212262200 . free .
- Miura Y, Gotoh E, Nara F, etal . Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. . FEBS Lett. . 557 . 1–3 . 288–92 . 2004 . 14741383 . 10.1016/S0014-5793(03)01523-0 . 34738077 . free .
- Marchesini N, Osta W, Bielawski J, etal . Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells . J. Biol. Chem. . 279 . 24 . 25101–11 . 2004 . 15051724 . 10.1074/jbc.M313662200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Jana A, Pahan K . Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase . J. Neurosci. . 24 . 43 . 9531–40 . 2005 . 15509740 . 10.1523/JNEUROSCI.3085-04.2004 . 1955476 .
- Krut O, Wiegmann K, Kashkar H, etal . Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein . J. Biol. Chem. . 281 . 19 . 13784–93 . 2006 . 16517606 . 10.1074/jbc.M511306200 . free .
- Levy M, Castillo SS, Goldkorn T . nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis . Biochem. Biophys. Res. Commun. . 344 . 3 . 900–5 . 2006 . 16631623 . 10.1016/j.bbrc.2006.04.013 . 4370275 .
- Clarke CJ, Truong TG, Hannun YA . Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2 . J. Biol. Chem. . 282 . 2 . 1384–96 . 2007 . 17085432 . 10.1074/jbc.M609216200 . free .
- Tani M, Hannun YA . Analysis of membrane topology of neutral sphingomyelinase 2 . FEBS Lett. . 581 . 7 . 1323–8 . 2007 . 17349629 . 10.1016/j.febslet.2007.02.046 . 1868537 .
- Filosto S, Fry W, Knowlton A, Goldkorn T . Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B) . J. Biol. Chem. . 285 . 14 . 10213–22 . 2010 . 20106976 . 2856226 . 10.1074/jbc.M109.069963 . free .
Notes and References
- Hofmann K, Tomiuk S, Wolff G, Stoffel W . Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase . Proc Natl Acad Sci U S A . 97 . 11 . 5895–900 . Jun 2000 . 10823942 . 18530 . 10.1073/pnas.97.11.5895 . 2000PNAS...97.5895H . free .
- Web site: Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II).