SMPD2 explained

Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.^{[1] [2]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Sawai H, Domae N, Nagan N, Hannun YA . Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C . The Journal of Biological Chemistry . 274 . 53 . 38131–9 . December 1999 . 10608884 . 10.1074/jbc.274.53.38131 . free .
• Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA . Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells . The Journal of Biological Chemistry . 279 . 24 . 25101–11 . June 2004 . 15051724 . 10.1074/jbc.M313662200 . free .
• Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S, Proksch E . Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis . The Journal of Investigative Dermatology . 122 . 6 . 1423–31 . June 2004 . 15175033 . 10.1111/j.0022-202X.2004.22621.x . free .
• Jana A, Pahan K . Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase . The Journal of Neuroscience . 24 . 43 . 9531–40 . October 2004 . 15509740 . 1955476 . 10.1523/JNEUROSCI.3085-04.2004 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Kim HT, Lee JY, Han BG, Kimm K, Oh B, Shin HD, Namkung JH, Kim E, Park T, Yang JM . Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans . Journal of Dermatological Science . 46 . 2 . 143–6 . May 2007 . 17212982 . 10.1016/j.jdermsci.2006.12.001 .
• Tani M, Hannun YA . Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization . The Journal of Biological Chemistry . 282 . 13 . 10047–56 . March 2007 . 17272284 . 10.1074/jbc.M611249200 . free .

Notes and References

1. Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W . Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? . Proceedings of the National Academy of Sciences of the United States of America . 95 . 7 . 3638–43 . March 1998 . 9520418 . 19888 . 10.1073/pnas.95.7.3638 . 1998PNAS...95.3638T . free .
2. Web site: Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase).