SMARCD2 explained

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.

Further reading

• Wang W, Côté J, Xue Y, etal . Purification and biochemical heterogeneity of the mammalian SWI-SNF complex . EMBO J. . 15 . 19 . 5370–82 . 1996 . 8895581 . 10.1002/j.1460-2075.1996.tb00921.x. 452280 .
• Surabhi RM, Daly LD, Cattini PA . Evidence for evolutionary conservation of a physical linkage between the human BAF60b, a subunit of SWI/SNF complex, and thyroid hormone receptor interacting protein-1 genes on chromosome 17 . Genome . 42 . 3 . 545–9 . 1999 . 10382302 . 10.1139/gen-42-3-545 .
• Bochar DA, Wang L, Beniya H, etal . BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer . Cell . 102 . 2 . 257–65 . 2000 . 10943845 . 10.1016/S0092-8674(00)00030-1 . 6500100 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nie Z, Yan Z, Chen EH, etal . Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner . Mol. Cell. Biol. . 23 . 8 . 2942–52 . 2003 . 12665591 . 10.1128/MCB.23.8.2942-2952.2003 . 152562 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR . Diversity and specialization of mammalian SWI/SNF complexes . Genes Dev . 10 . 17 . 2117–30 . Nov 1996 . 8804307 . 10.1101/gad.10.17.2117 . free .
2. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U . Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome . Genomics . 51 . 1 . 140–3 . Sep 1998 . 9693044 . 10.1006/geno.1998.5343 . free .
3. Web site: Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2.