SMARCD1 explained

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

SMARCD1 has been shown to interact with Glucocorticoid receptor.

Further reading

• Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .
• Wang W, Côté J, Xue Y, etal . Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. . EMBO J. . 15 . 19 . 5370–82 . 1996 . 8895581 . 10.1002/j.1460-2075.1996.tb00921.x. 452280 .
• Cho H, Orphanides G, Sun X, etal . A human RNA polymerase II complex containing factors that modify chromatin structure. . Mol. Cell. Biol. . 18 . 9 . 5355–63 . 1998 . 9710619 . 10.1128/MCB.18.9.5355. 109120 .
• O'Neill D, Yang J, Erdjument-Bromage H, etal . Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 2 . 349–54 . 1999 . 9892636 . 10.1073/pnas.96.2.349 . 15139 . 1999PNAS...96..349O . free .
• Phelan ML, Sif S, Narlikar GJ, Kingston RE . Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. . Mol. Cell . 3 . 2 . 247–53 . 1999 . 10078207 . 10.1016/S1097-2765(00)80315-9 . free .
• Ito T, Yamauchi M, Nishina M, etal . Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. . J. Biol. Chem. . 276 . 4 . 2852–7 . 2001 . 11053448 . 10.1074/jbc.M009633200 . free .
• Xue Y, Canman JC, Lee CS, etal . The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 24 . 13015–20 . 2001 . 11078522 . 10.1073/pnas.240208597 . 27170 . 2000PNAS...9713015X . free .
• Kato H, Tjernberg A, Zhang W, etal . SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. . J. Biol. Chem. . 277 . 7 . 5498–505 . 2002 . 11734557 . 10.1074/jbc.M108702200 . free . 2066/170683 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nie Z, Yan Z, Chen EH, etal . Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. . Mol. Cell. Biol. . 23 . 8 . 2942–52 . 2003 . 12665591 . 10.1128/MCB.23.8.2942-2952.2003 . 152562 .
• Chien CY, Liu WK, Chou CK, Su JY . The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. . FEBS Lett. . 543 . 1–3 . 55–60 . 2003 . 12753905 . 10.1016/S0014-5793(03)00401-0 . 31400521 . free .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J . FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. . J. Biol. Chem. . 281 . 15 . 9869–81 . 2006 . 16484223 . 10.1074/jbc.M513280200 . free .

Notes and References

1. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR . Diversity and specialization of mammalian SWI/SNF complexes . Genes Dev . 10 . 17 . 2117–30 . Nov 1996 . 8804307 . 10.1101/gad.10.17.2117 . free .
2. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U . Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome . Genomics . 51 . 1 . 140–3 . Sep 1998 . 9693044 . 10.1006/geno.1998.5343 . free .
3. Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK . BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation . Mol Cell Biol . 23 . 17 . 6210–20 . Aug 2003 . 12917342 . 180928 . 10.1128/MCB.23.17.6210-6220.2003 .
4. Web site: Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1.
5. Web site: Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1.