SMARCC1 explained

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and contains a predicted leucine zipper motif typical of many transcription factors.

Interactions

SMARCC1 has been shown to interact with:

• BAZ1B,^[3]
• ING1,
• SIN3A,^{[4] [5]}
• SMARCA2,^{[5] [6]}
• SMARCA4,^{[5] [6] [7] [8]} and
• SMARCB1.^{[5] [6]}

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR . Purification and biochemical heterogeneity of the mammalian SWI-SNF complex . EMBO J. . 15 . 19 . 5370–82 . 1996 . 8895581 . 452280 . 10.1002/j.1460-2075.1996.tb00921.x.
• Fryer CJ, Archer TK . Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex . Nature . 393 . 6680 . 88–91 . 1998 . 9590696 . 10.1038/30032 . 1998Natur.393...88F . 2208522 .
• Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U . Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome . Genomics . 51 . 1 . 140–3 . 1998 . 9693044 . 10.1006/geno.1998.5343 . free .
• Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D . A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure . Mol. Cell. Biol. . 18 . 9 . 5355–63 . 1998 . 9710619 . 109120 . 10.1128/MCB.18.9.5355.
• Sif S, Stukenberg PT, Kirschner MW, Kingston RE . Mitotic inactivation of a human SWI/SNF chromatin remodeling complex . Genes Dev. . 12 . 18 . 2842–51 . 1998 . 9744861 . 317164 . 10.1101/gad.12.18.2842 .
• Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E . Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest . Mol. Cell. Biol. . 19 . 2 . 1460–9 . 1999 . 9891079 . 116074 . 10.1128/mcb.19.2.1460.
• Phelan ML, Sif S, Narlikar GJ, Kingston RE . Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits . Mol. Cell . 3 . 2 . 247–53 . 1999 . 10078207 . 10.1016/S1097-2765(00)80315-9 . free .
• Kowenz-Leutz E, Leutz A . A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes . Mol. Cell . 4 . 5 . 735–43 . 2000 . 10619021 . 10.1016/S1097-2765(00)80384-6 . free .
• Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R . BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer . Cell . 102 . 2 . 257–65 . 2000 . 10943845 . 10.1016/S0092-8674(00)00030-1 . 6500100 . free .
• Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM . Functional selectivity of recombinant mammalian SWI/SNF subunits . Genes Dev. . 14 . 19 . 2441–51 . 2000 . 11018012 . 316972 . 10.1101/gad.828000 .
• Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W . The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes . Proc. Natl. Acad. Sci. U.S.A. . 97 . 24 . 13015–20 . 2001 . 11078522 . 27170 . 10.1073/pnas.240208597 . 2000PNAS...9713015X . free .
• Sif S, Saurin AJ, Imbalzano AN, Kingston RE . Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes . Genes Dev. . 15 . 5 . 603–18 . 2001 . 11238380 . 312641 . 10.1101/gad.872801 .
• Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM . Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex . Hum. Mol. Genet. . 10 . 23 . 2651–60 . 2002 . 11726552 . 10.1093/hmg/10.23.2651 . free .
• Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG . SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones . J. Biol. Chem. . 277 . 7 . 5498–505 . 2002 . 11734557 . 10.1074/jbc.M108702200 . free . 2066/170683 . free .
• Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W . Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner . Mol. Cell. Biol. . 23 . 8 . 2942–52 . 2003 . 12665591 . 152562 . 10.1128/MCB.23.8.2942-2952.2003 .
• Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK . BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation . Mol. Cell. Biol. . 23 . 17 . 6210–20 . 2003 . 12917342 . 180928 . 10.1128/MCB.23.17.6210-6220.2003 .

Notes and References

1. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR . Diversity and specialization of mammalian SWI/SNF complexes . Genes Dev . 10 . 17 . 2117–30 . November 1996 . 8804307 . 10.1101/gad.10.17.2117 . free .
2. Web site: Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1.
3. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S . The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome . Cell . 113 . 7 . 905–17 . June 2003 . 12837248 . 10.1016/s0092-8674(03)00436-7. free .
4. Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D . Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) . Mol. Cell. Biol. . 22 . 3 . 835–48 . February 2002 . 11784859 . 133546 . 10.1128/mcb.22.3.835-848.2002.
5. Sif S, Saurin AJ, Imbalzano AN, Kingston RE . Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes . Genes Dev. . 15 . 5 . 603–18 . March 2001 . 11238380 . 312641 . 10.1101/gad.872801 .
6. Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR . Purification and biochemical heterogeneity of the mammalian SWI-SNF complex . EMBO J. . 15 . 19 . 5370–82 . October 1996 . 8895581 . 452280 . 10.1002/j.1460-2075.1996.tb00921.x.
7. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM . Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex . Hum. Mol. Genet. . 10 . 23 . 2651–60 . November 2001 . 11726552 . 10.1093/hmg/10.23.2651. free .
8. Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR . Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling . Cell . 95 . 5 . 625–36 . November 1998 . 9845365 . 10.1016/s0092-8674(00)81633-5. 3184211 . free .