SMARCA1 explained
Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.[1] [2] [3]
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.
Further reading
- Bozhenok L, Wade PA, Varga-Weisz P . WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. . EMBO J. . 21 . 9 . 2231–41 . 2002 . 11980720 . 10.1093/emboj/21.9.2231 . 125993 .
- Maguire PB, Wynne KJ, Harney DF, etal . Identification of the phosphotyrosine proteome from thrombin activated platelets. . Proteomics . 2 . 6 . 642–8 . 2003 . 12112843 . 10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I . 22665513 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Barak O, Lazzaro MA, Cooch NS, etal . A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling. . J. Biol. Chem. . 279 . 43 . 45130–8 . 2004 . 15310751 . 10.1074/jbc.M406212200 . free .
- Wang F, Zhang R, Beischlag TV, etal . Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. . J. Biol. Chem. . 279 . 45 . 46733–41 . 2004 . 15347669 . 10.1074/jbc.M409002200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Banting GS, Barak O, Ames TM, etal . CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. . Hum. Mol. Genet. . 14 . 4 . 513–24 . 2005 . 15640247 . 10.1093/hmg/ddi048 . free .
- Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome. . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
- Lazzaro MA, Pépin D, Pescador N, etal . The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. . Mol. Endocrinol. . 20 . 10 . 2406–17 . 2006 . 16740656 . 10.1210/me.2005-0213 . free .
Notes and References
- Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL . Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae . Nucleic Acids Res . 20 . 17 . 4649–55 . Oct 1992 . 1408766 . 334196 . 10.1093/nar/20.17.4649 .
- Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R . Isolation of human NURF: a regulator of Engrailed gene expression . EMBO J . 22 . 22 . 6089–100 . Nov 2003 . 14609955 . 275440 . 10.1093/emboj/cdg582 .
- Web site: Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1.