Zinc finger FYVE domain-containing protein 9 explained

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.^[1] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.^[2] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Zinc finger FYVE domain-containing protein 9

Notes and References

1. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL . SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor . Cell . 95 . 6 . 779–791 . December 1998 . 9865696 . 10.1016/S0092-8674(00)81701-8 . 6194655 . free .
2. Lin HK, Bergmann S, Pandolfi PP . Cytoplasmic PML function in TGF-beta signalling . Nature . 431 . 7005 . 205–211 . September 2004 . 15356634 . 10.1038/nature02783 . 2004Natur.431..205L . 4301789 .