SLU7 explained

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.^{[1] [2] [3]}

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.^[4]

Further reading

• Alberstein M, Amit M, Vaknin K, etal . Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. . RNA . 13 . 11 . 1988–99 . 2008 . 17804646 . 10.1261/rna.492907 . 2040095 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Shomron N, Reznik M, Ast G . Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. . Mol. Biol. Cell . 15 . 8 . 3782–95 . 2005 . 15181151 . 10.1091/mbc.E04-02-0152 . 491837 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chua K, Reed R . An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. . Mol. Cell. Biol. . 21 . 5 . 1509–14 . 2001 . 11238888 . 10.1128/MCB.21.5.1509-1514.2001 . 86697 .
• Chua K, Reed R . The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. . Nature . 402 . 6758 . 207–10 . 2000 . 10647016 . 10.1038/46086 . 4428185 .

Notes and References

1. Chua K, Reed R . Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing . Genes Dev . 13 . 7 . 841–50 . May 1999 . 10197984 . 316594 . 10.1101/gad.13.7.841 .
2. Shomron N, Alberstein M, Reznik M, Ast G . Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing . J Cell Sci . 118 . Pt 6 . 1151–9 . Mar 2005 . 15728250 . 10.1242/jcs.01720 . 18873022 .
3. Web site: Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae).
4. Web site: Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae).