SLU-PP-332 explained

SLU-PP-332 is a compound which is a potent but non-selective estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting a possible role for compounds from this class as medications for the treatment of obesity.[1] [2] [3] [4] [5]

Notes and References

  1. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors. . Zhi L, Hudson AR, Van Oeveren CA, Roach SL, Pickens JC, Shen Y, Cuervo C, Valdez LJ, Basinger J, Grant VH . US . 8680150 . 25 March 2014 . Ligand Pharmaceuticals Inc. .
  2. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP . 6 . Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity . ACS Chemical Biology . 18 . 4 . 756–771 . April 2023 . 36988910 . 10.1021/acschembio.2c00720 . 257803892 .
  3. Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP . 6 . A Synthetic ERR Agonist Alleviates Metabolic Syndrome . The Journal of Pharmacology and Experimental Therapeutics . 388. 2. September 2023 . 232–240 . 37739806 . 10.1124/jpet.123.001733 . 262147173 . free .
  4. Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M . 6 . Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney . The American Journal of Pathology . 193. 12. September 2023 . 1969–1987 . 37717940 . 10.1016/j.ajpath.2023.07.008 . 10734281 . December 1, 2024 . 262046570 .
  5. Web site: Exercise-mimicking drug sheds weight, boosts muscle activity in mice . 2023-10-05 . news.ufl.edu . en.

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