SLK (gene) explained

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.^{[1] [2]}

Interactions

SLK (gene) has been shown to interact with PDZK1.^[3]

SLK is a mammalian gene located on chromosome 10. it has also been cloned in rats.^[4] There is a whole family of STE20 like protein kinases, which has been divided into three categories. the most important p21-activated kinase (PAK), germinal center kinases (GCK) and Pleckstrin homology domain containing PAK (PHPAK).^[5] SLK gene plays an important role in development, termination and differentiation of cells and tissues. the main enzyme SLK gene produces is called Ste20-like kinases which was formerly known as Ste20-like serine/threonine protein kinase. the balanced expression of SLK gene is very essential for the correct development of body parts in all mammals. this enzyme is also involved in cell movement and cell cycle. The expression of SLK gene in germ line cell is regulated by phosphorylation of PLK1, which is another gene involved in mitosis. Ste20- like kinases manages the correct orientation of micro-tubules during inter-phase level of cell cycles. Underproduction of Ste20-like serine/threonine-protein kinases can result in micro-tubule fibers to detach from chromosomes. It also functions in activation/deactivation of apoptosis in cells, as well as organization and adhesion of cell to shape an appropriate organ.

^{[6] [7]}

Further reading

• Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D . Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1769 . 2 . 106–16 . Feb 2007 . 17321610 . 1865517 . 10.1016/j.bbaexp.2007.01.003 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Chaar Z, O'reilly P, Gelman I, Sabourin LA . v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II . The Journal of Biological Chemistry . 281 . 38 . 28193–9 . Sep 2006 . 16837460 . 10.1074/jbc.M605665200 . free .
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H . PDZK1: I. a major scaffolder in brush borders of proximal tubular cells . Kidney International . 64 . 5 . 1733–45 . Nov 2003 . 14531806 . 10.1046/j.1523-1755.2003.00266.x . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Research . 12 . 11 . 1773–84 . Nov 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Dan I, Watanabe NM, Kusumi A . The Ste20 group kinases as regulators of MAP kinase cascades . Trends in Cell Biology . 11 . 5 . 220–30 . May 2001 . 11316611 . 10.1016/S0962-8924(01)01980-8 .
• Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D . Serological detection of cutaneous T-cell lymphoma-associated antigens . Proceedings of the National Academy of Sciences of the United States of America . 98 . 2 . 629–34 . Jan 2001 . 11149944 . 14639 . 10.1073/pnas.021386498 . free .
• Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H . Molecular cloning and characterization of a novel human STE20-like kinase, hSLK . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1495 . 3 . 250–62 . Feb 2000 . 10699464 . 10.1016/S0167-4889(99)00164-0 . free .
• Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA . Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region . Molecular and Cellular Biology . 20 . 2 . 684–96 . Jan 2000 . 10611247 . 85169 . 10.1128/MCB.20.2.684-696.2000 .
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Research . 3 . 5 . 321–9, 341–54 . Oct 1996 . 9039502 . 10.1093/dnares/3.5.321 . free . 10.1.1.319.3770 .

Notes and References

1. Celenza JL, Carlson M . A yeast gene that is essential for release from glucose repression encodes a protein kinase . Science . 233 . 4769 . 1175–80 . Sep 1986 . 3526554 . 10.1126/science.3526554 . 1986Sci...233.1175C .
2. Web site: Entrez Gene: SLK STE20-like kinase (yeast).
3. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H . PDZK1: I. a major scaffolder in brush borders of proximal tubular cells . Kidney International . 64 . 5 . 1733–45 . Nov 2003 . 14531806 . 10.1046/j.1523-1755.2003.00266.x . free .
4. Ste20-like kinases SLK, at the crossroad
5. Al‐Zahrani, Sekhon. “Essential Role for the SLK Protein Kinase in Embryogenesis and Placental Tissue Development.” Developmental Dynamics, vol. 243, no. 5, Wiley Subscription Services, Inc, May 2014, pp. 640–51, doi:10.1002/dvdy.24106
6. Cybulsky, Papillon. “Ste20-Like Kinase, SLK, a Novel Mediator of Podocyte Integrity.” American Journal of Physiology. Renal Physiology, vol. 315, no. 1, American Physiological Society, July 2018, pp. F186–F198, doi:10.1152/ajprenal.00238.2017
7. Cybulsky, Takano. “The Ste20-Like Kinase SLK Promotes P53 Transactivation and Apoptosis.” American Journal of Physiology. Renal Physiology 297.4 (2009): 971–980. Web